New Invasive Nemertean Species (Cephalothrix Simula) in England with High Levels of Tetrodotoxin and a Microbiome Linked to Toxin Metabolism [PDF]
Marine Drugs, 2018 The marine nemertean Cephalothrix simula originates from the Pacific Ocean but in recent years has been discovered in northern Europe. The species has been associated with high levels of the marine neurotoxin Tetrodotoxin, traditionally associated with ...
Andrew D. Turner +10 more
doaj +2 more sources
Tese de mestrado, Ecologia Marinha, 2024, Universidade de Lisboa, Faculdade de ...
Pais, Maria de Fátima Ferreira
core +3 more sources
Identification of Deoxy- and <i>epi</i>-Tetrodotoxin Analogues from the Newt <i>Cynops ensicauda popei</i> Suggests Stepwise Oxidation in Terrestrial Tetrodotoxin Biosynthesis. [PDF]
J Nat ProdTetrodotoxin (TTX, 1) is a potent neurotoxin that selectively blocks voltage-gated sodium channels and occurs in various marine and terrestrial organisms, yet its biosynthetic pathway remains unresolved. In this study, five deoxy-type TTX analogues were identified from the toxic newt Cynops ensicauda popei.
Horie S +5 more
europepmc +3 more sources
Toxins, 2021 Nemertea is a phylum of marine worms whose members bear various toxins, including tetrodotoxin (TTX) and its analogues. Despite the more than 30 years of studying TTXs in nemerteans, many questions regarding their functions and the mechanisms ensuring ...
Anna E. Vlasenko +6 more
doaj +1 more source
Intracellular immunohistochemical detection of tetrodotoxin in Pleurobranchaea maculata (Gastropoda) and Stylochoplana sp. (Turbellaria) [PDF]
, 2015 Tetrodotoxin (TTX), is a potent neurotoxin targeting sodium channels that has been identified in multiple marine and terrestrial organisms. It was recently detected in the Opisthobranch Pleurobranchaea maculata and a Platyhelminthes Stylochoplana sp ...
Cary, Stephen Craig +11 more
core +1 more source
Case of Paraesthesia Developed After Consuming Pufferfish
Türk Yoğun Bakim Derneği Dergisi, 2021 Pufferfish, also known globally as ballfish, globefish and toadfish, is a fish species belonging to the Tetrodontiformes family. Following the consumption of this fish, tetrodotoxin (TTX), a type of neurotoxin, causes a rare type of intoxication.
Mehmet Murat Çelik +6 more
doaj +1 more source
Structures of N-Hydroxy-Type Tetrodotoxin Analogues and Bicyclic Guanidinium Compounds Found in Toxic Newts [PDF]
Journal of Natural Products, 2020 The biosynthesis of tetrodotoxin (TTX, 1), a potent neurotoxin widely distributed in marine and terrestrial metazoans, remains unresolved. A significant issue has been identifying intermediates and shunt products associated with the biosynthetic pathway of TTX. We investigated TTX biosynthesis by screening and identifying new TTX-related compounds from
Yuta Kudo +3 more
openaire +2 more sources
Current situation on analysis of marine toxins
Reviews in Analytical Chemistry, 2013 Marine toxins are a food safety concern worldwide. This review discusses current analytical methods for those toxins that are legally regulated in Europe, namely domoic acid, saxitoxin, okadaic acid, yessotoxin, pectenotoxin and azaspiracids, and all ...
Botana Ana M. +4 more
doaj +1 more source
Mutational analysis of the analgesic peptide DrTx(1-42) revealing a functional role of the amino-terminal turn. [PDF]
PLoS ONE, 2012 BACKGROUND: DrTx(1-42) (a carboxyl-terminally truncated version of drosotoxin) is a potent and selective blocker of tetrodotoxin-resistant (TTX-R) Na(+) channels in rat dorsal root ganglion neurons with analgesic activity. This purpose is to identify key
Ping Li, Shunyi Zhu
doaj +1 more source
, 2015 Tetrodotoxin (TTX) is a potent neurotoxin found in the tissues of many taxonomically diverse organisms. Its origin has been the topic of much debate, with suggestions including endogenous production, acquisition through diet, and symbiotic bacterial ...
Salvitti, Lauren R. +10 more
core +1 more source