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Infectious diseases are commonly cited as significant contributors to wildlife population declines. It is, therefore, important to investigate the extent to which tools designed to mitigate the effects of infectious diseases explain wildlife responses to habitat management.
Jacob Goldman+8 more
wiley +1 more source
Zika Virus: A New Chapter in the History of Medicine
Keywords: Aedes; Arboviruses; Flavivirus; Flaviviridae Infections.
Carlos Brito
doaj +1 more source
ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. [PDF]
BACKGROUND: Many viruses depend on the extensive membranous network of the endoplasmic reticulum (ER) for their translation, replication, and packaging. Certain membrane modifications of the ER can be a trigger for ER stress, as well as the accumulation ...
Fu, Z+11 more
core +1 more source
Maltase 1 regulates DENV2 infection and life history in Aedes aegypti
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li+5 more
wiley +1 more source
Flaviviridae — addition to the family
This review article analyzes and summarizes the history of the replenishment of the family Flaviviridae with new members over the last several decades on the example of the youngest genera of this family - Hepacivirus and Pegivirus .It all started in 1966 when surgeon George Barker, who had hepatitis, had blood serum taken in containing an unknown ...
openaire +3 more sources
Current Flavivirus Research Important for Vaccine Development
The Flaviviridae family of RNA viruses includes numerous human disease-causing pathogens that largely are increasing in prevalence due to continual climate change, rising population sizes and improved ease of global travel [...]
Elizabeth Geerling+3 more
doaj +1 more source
Experimental Zika Virus Infection in the Pregnant Common Marmoset Induces Spontaneous Fetal Loss and Neurodevelopmental Abnormalities. [PDF]
During its most recent outbreak across the Americas, Zika virus (ZIKV) was surprisingly shown to cause fetal loss and congenital malformations in acutely and chronically infected pregnant women.
Aagaard, Kjersti M+17 more
core +2 more sources
ABSTRACT Tail fan necrosis (TFN) is a shell disease affecting spiny lobsters' outer integument, with significant implications for the health and commercial viability of red rock lobsters (Jasus edwardsii) in New Zealand. Despite its impact, the potential role of a microbial agent in TFN remains poorly understood.
Rebecca M. Grimwood+6 more
wiley +1 more source
Non-primate hepacivirus infection with apparent hepatitis in a horse — Short communication [PDF]
Non-primate hepacivirus (NPHV) is a recently identified hepacivirus (family Flaviviridae) in dog and horse; however, the disease associations remain unknown.
Boros, Ákos+3 more
core +1 more source
Harnessing Viral Proteases for Cellular and Molecular Engineering
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui+2 more
wiley +1 more source