Complete replication of hepatitis C virus in cell culture. [PDF]
, 2005 Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen.
Burton, Dennis R +10 more
core +1 more source
Presence, Location and Conservation of Putative G-Quadruplex Forming Sequences in Arboviruses Infecting Humans [PDF]
, 2023 Guanine quadruplexes (G4s) are non-canonical nucleic acid structures formed by guanine (G)-rich tracts that assemble into a core of stacked planar tetrads.
Frasson, Ilaria +2 more
core +1 more source
Zika Virus: A New Chapter in the History of Medicine
Acta Médica Portuguesa, 2016 Keywords: Aedes; Arboviruses; Flavivirus; Flaviviridae Infections.
Carlos Brito
doaj +1 more source
Immunogenicity of NS4b dengue 3 virus mimotope presented to the immune system as multiple antigen peptide system [PDF]
, 2013 The availability of random peptide libraries displayed on bacteriophage (RPL) has provided a powerful tool for selecting sequences that mimic binding properties of natural antigen epitopes (mimotopes). These mimotopes can be used for vaccine design, drug
Acosta, Armando +11 more
core +2 more sources
Flaviviridae — addition to the family
Health and Ecology Issues, 2019 This review article analyzes and summarizes the history of the replenishment of the family Flaviviridae with new members over the last several decades on the example of the youngest genera of this family - Hepacivirus and Pegivirus .It all started in 1966 when surgeon George Barker, who had hepatitis, had blood serum taken in containing an unknown ...
openaire +3 more sources
Current Flavivirus Research Important for Vaccine Development
Vaccines, 2020 The Flaviviridae family of RNA viruses includes numerous human disease-causing pathogens that largely are increasing in prevalence due to continual climate change, rising population sizes and improved ease of global travel [...]
Elizabeth Geerling +3 more
doaj +1 more source
Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil [PDF]
, 2016 Background: The outbreak of Zika virus (ZIKV) in the Americas has transformed a previously obscure mosquito-transmitted arbovirus of the Flaviviridae family into a major public health concern.
Biek, Roman +24 more
core +3 more sources
Diverse hepatitis C virus glycoproteins mediate viral infection in a CD81-dependent manner [PDF]
, 2004 We recently reported that retroviral pseudotypes bearing the hepatitis C virus (HCV) strain H and Con1 glycoproteins, genotype 1a and 1b, respectively, require CD81 as a coreceptor for virus-cell entry and infection.
Balfe, Peter +10 more
core +2 more sources
G protein-coupled receptor kinase 2 promotes flaviviridae entry and replication. [PDF]
PLoS Neglected Tropical Diseases, 2012 Flaviviruses cause a wide range of severe diseases ranging from encephalitis to hemorrhagic fever. Discovery of host factors that regulate the fate of flaviviruses in infected cells could provide insight into the molecular mechanisms of infection and ...
Caroline Le Sommer +4 more
doaj +1 more source
The interferon-stimulated gene IFITM3 restricts West Nile virus infection and pathogenesis [PDF]
, 2016 The interferon-induced transmembrane protein (IFITM) family of proteins inhibit infection of several different enveloped viruses in cell culture by virtue of their ability to restrict entry and fusion from late endosomes.
Bradbury LE +6 more
core +2 more sources