Flavivirus NS1 and Its Potential in Vaccine Development
Vaccines, 2021 The Flavivirus genus contains many important human pathogens, including dengue, Japanese encephalitis (JE), tick-borne encephalitis (TBE), West Nile (WN), yellow fever (YF) and Zika (ZIK) viruses.
Kassandra L. Carpio, Alan D. T. Barrett
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A Perspective on Current Flavivirus Vaccine Development: A Brief Review
Viruses, 2023 The flavivirus genus contains several clinically important pathogens that account for tremendous global suffering. Primarily transmitted by mosquitos or ticks, these viruses can cause severe and potentially fatal diseases ranging from hemorrhagic fevers ...
Sudip Kumar Dutta, Thomas Langenburg
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Flavivirus: From Structure to Therapeutics Development
Life, 2021 Flaviviruses are still a hidden threat to global human safety, as we are reminded by recent reports of dengue virus infections in Singapore and African-lineage-like Zika virus infections in Brazil.
Rong Zhao +6 more
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Viruses, 2021 Flaviviruses are known to cause a variety of diseases in humans in different parts of the world. There are very limited numbers of antivirals to combat flavivirus infection, and therefore new drug targets must be explored.
Abdul Wahaab +8 more
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Serological Diagnosis of Flavivirus-Associated Human Infections
Diagnostics, 2020 Arthropod-borne viruses (arboviruses) belonging to the Flavivirus genus of the Flaviviridae family, are a major public health threat in tropical and subtropical regions, and have recently become a medical concern in temperate zones. Most flaviviruses are
Didier Musso, Philippe Desprès
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Evaluating the specificity of flavivirus proteases in Aedes aegypti cells for dengue virus 2-derived cleavage sites. [PDF]
PLoS ONEFlaviviruses are a diverse group of RNA viruses known for their significant impact on human health worldwide. We generated a series of reporters that included cleavage sequences from the dengue virus type 2 polyprotein and co-transfected with plasmids ...
Alexius O Dingle, Zach N Adelman
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Impact of flavivirus vaccine-induced immunity on primary Zika virus antibody response in humans.
PLoS Neglected Tropical Diseases, 2020 BackgroundZika virus has recently spread to South- and Central America, causing congenital birth defects and neurological complications. Many people at risk are flavivirus pre-immune due to prior infections with other flaviviruses (e.g.
Stefan Malafa +14 more
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Immunological and Safety Considerations When Selecting the Dose Formulation of a Purified Inactivated Zika Virus Vaccine (PIZV) [PDF]
MicroorganismsWe previously reported the first-in-human assessment of three doses (2, 5, and 10 µg) of purified inactivated Zika virus vaccine (PIZV or TAK-426) in the Phase 1 ZIK-101 study (NCT03343626).
Camilo J. Acosta +5 more
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Flavivirus NS1 Triggers Tissue-Specific Vascular Endothelial Dysfunction Reflecting Disease Tropism
Cell Reports, 2019 Summary: Flaviviruses cause systemic or neurotropic-encephalitic pathology in humans. The flavivirus nonstructural protein 1 (NS1) is a secreted glycoprotein involved in viral replication, immune evasion, and vascular leakage during dengue virus ...
Henry Puerta-Guardo +8 more
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Phenotypic and Genetic Variability of Isolates of ZIKV-2016 in Brazil
Microorganisms, 2022 The possibility of a Zika virus epidemic resurgence requires studies to understand its mechanisms of pathogenicity. Here, we describe the isolation of the Zika virus from breast milk (Rio-BM1) and compare its genetic and virological properties with two ...
Lidiane Menezes Souza Raphael +11 more
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