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Flavivirus: From Structure to Therapeutics Development
Life, 2021 Flaviviruses are still a hidden threat to global human safety, as we are reminded by recent reports of dengue virus infections in Singapore and African-lineage-like Zika virus infections in Brazil.
Rong Zhao +6 more
doaj +2 more sources
Flavivirus NS1 and Its Potential in Vaccine Development
Vaccines, 2021 The Flavivirus genus contains many important human pathogens, including dengue, Japanese encephalitis (JE), tick-borne encephalitis (TBE), West Nile (WN), yellow fever (YF) and Zika (ZIK) viruses.
Kassandra L. Carpio, Alan D. T. Barrett
doaj +2 more sources
A Perspective on Current Flavivirus Vaccine Development: A Brief Review
Viruses, 2023 The flavivirus genus contains several clinically important pathogens that account for tremendous global suffering. Primarily transmitted by mosquitos or ticks, these viruses can cause severe and potentially fatal diseases ranging from hemorrhagic fevers ...
Sudip Kumar Dutta, Thomas Langenburg
doaj +2 more sources
Viruses, 2021 Flaviviruses are known to cause a variety of diseases in humans in different parts of the world. There are very limited numbers of antivirals to combat flavivirus infection, and therefore new drug targets must be explored.
Abdul Wahaab +8 more
doaj +2 more sources
Serological Diagnosis of Flavivirus-Associated Human Infections
Diagnostics, 2020 Arthropod-borne viruses (arboviruses) belonging to the Flavivirus genus of the Flaviviridae family, are a major public health threat in tropical and subtropical regions, and have recently become a medical concern in temperate zones. Most flaviviruses are
Didier Musso, Philippe Desprès
doaj +2 more sources
Phenotypic and Genetic Variability of Isolates of ZIKV-2016 in Brazil
Microorganisms, 2022 The possibility of a Zika virus epidemic resurgence requires studies to understand its mechanisms of pathogenicity. Here, we describe the isolation of the Zika virus from breast milk (Rio-BM1) and compare its genetic and virological properties with two ...
Lidiane Menezes Souza Raphael +11 more
doaj +1 more source
Chikungunya Virus Shedding in Semen: A Case Series
Viruses, 2022 Background: Chikungunya is a viral disease that is transmitted by mosquitoes. It is characterized by an acute onset of fever and severe arthralgia. Methods: We describe six cases of acute and post-acute chikungunya in which viral RNA was detected in ...
Ezequias B. Martins +16 more
doaj +1 more source
Recombinant Envelope-Proteins with Mutations in the Conserved Fusion Loop Allow Specific Serological Diagnosis of Dengue-Infections [PDF]
, 2015 Dengue virus (DENV) is a mosquito-borne flavivirus and a major international public health concern in many tropical and sub-tropical areas worldwide. DENV is divided into four major serotypes, and infection with one serotype leads to immunity against the
Barzon, Luisa +5 more
core +12 more sources
The Role of NS1 Protein in the Diagnosis of Flavivirus Infections
Viruses, 2023 Nonstructural protein 1 (NS1) is a glycoprotein among the flavivirus genus. It is found in both membrane-associated and soluble secreted forms, has an essential role in viral replication, and modulates the host immune response.
Ron Fisher +3 more
semanticscholar +1 more source
Secretory pathways and multiple functions of nonstructural protein 1 in flavivirus infection
Frontiers in Immunology, 2023 The genus Flavivirus contains a wide variety of viruses that cause severe disease in humans, including dengue virus, yellow fever virus, Zika virus, West Nile virus, Japanese encephalitis virus and tick-borne encephalitis virus.
Senzhao Zhang +18 more
semanticscholar +1 more source