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Astrocytes in Flavivirus Infections [PDF]
International Journal of Molecular Sciences, 2019 Virus infections of the central nervous system (CNS) can manifest in various forms of inflammation, including that of the brain (encephalitis) and spinal cord (myelitis), all of which may have long-lasting deleterious consequences. Although the knowledge of how different viruses affect neural cells is increasing, understanding of the mechanisms by ...
Maja Potokar +2 more
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Pathogenesis and virulence of flavivirus infections [PDF]
Virulence, 2021 The Flavivirus genus consists of >70 members including several that are considered significant human pathogens. Flaviviruses display a broad spectrum of diseases that can be roughly categorised into two phenotypes - systemic disease involving haemorrhage exemplified by dengue and yellow Fever virus, and neurological complications associated with the ...
van Leur, SW +3 more
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Flavivirus: From Structure to Therapeutics Development
Life, 2021 Flaviviruses are still a hidden threat to global human safety, as we are reminded by recent reports of dengue virus infections in Singapore and African-lineage-like Zika virus infections in Brazil.
Rong Zhao +6 more
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Serological Diagnosis of Flavivirus-Associated Human Infections
Diagnostics, 2020 Arthropod-borne viruses (arboviruses) belonging to the Flavivirus genus of the Flaviviridae family, are a major public health threat in tropical and subtropical regions, and have recently become a medical concern in temperate zones. Most flaviviruses are
Didier Musso, Philippe Desprès
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Viruses, 2021 The Flavivirus genus includes a number of important viruses that are pathogenic to humans and animals and are responsible for outbreaks across the globe.
Vinicius Pinho dos Reis +4 more
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Memory T Cells in Flavivirus Vaccination [PDF]
Vaccines, 2018 Flaviviruses include many medically important viruses, such as Dengue virus (DENV), Japanese encephalitis (JEV), tick-borne encephalitis (TBEV), West Nile (WNV), yellow fever (YFV), and Zika viruses (ZIKV). Currently, there are licensed human vaccines for DENV, JEV, TBEV and YFV, but not for WNV or ZIKV.
Guangyu Li, Cody Teleki, Tian Wang
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30 years of dengue fatal cases in Brazil: a laboratorial-based investigation of 1047 cases
BMC Infectious Diseases, 2018 Background Dengue viruses (DENV) have emerged and reemerged in Brazil in the past 30 years causing explosive epidemics. The disease may range from clinically asymptomatic infections to severe and fatal outcomes.
Priscila Conrado Guerra Nunes +14 more
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Flavivirus enzymes and their inhibitors
, 2021 Flaviviruses such as dengue, Japanese encephalitis, West Nile, Yellow Fever and Zika virus, cause viral hemorrhagic fever and encephalitis in humans. However, antiviral therapeutics to treat or prevent flavivirus infections are not yet available. Thus, there is pressing need to develop therapeutics and vaccines that target flavivirus infections.
Marc C. Morais +2 more
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Flavivirus NS1 and Its Potential in Vaccine Development
Vaccines, 2021 The Flavivirus genus contains many important human pathogens, including dengue, Japanese encephalitis (JE), tick-borne encephalitis (TBE), West Nile (WN), yellow fever (YF) and Zika (ZIK) viruses.
Kassandra L. Carpio, Alan D. T. Barrett
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Flavivirus Susceptibility in Aedes aegypti [PDF]
Archives of Medical Research, 2002 Aedes aegypti is the primary vector of yellow fever (YF) and dengue fever (DF) flaviviruses worldwide. In this review we focus on past and present research on genetic components and environmental factors in Aedes aegypti that appear to control flavivirus transmission. We review genetic relationships among Ae.
Black, William C. +8 more
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