Results 31 to 40 of about 6,613 (229)

Differential Roles of a Family of Flavodoxin-Like Proteins That Promote Resistance to Quinone-Mediated Oxidative Stress in Candida albicans

Infection and Immunity, 2021
Survival of the fungal pathogen Candida albicans within a mammalian host relies on its ability to resist oxidative stress. The four flavodoxin-like proteins (Pst1, Pst2, Pst3, and Ycp4) that reside on the inner surface of the C.
Jenna E. Foderaro, J. Konopka
semanticscholar   +1 more source

Biosynthesis of the Biphenomycin Family of Potent Antibiotics. [PDF]

Angew Chem Int Ed Engl
The complete biosynthetic pathway of the biphenomycin antibiotics is elucidated, revealing a unique enzymatic machinery featuring a bifunctional MNIO, a regioselective arginase, a B12‐dependent rSAM for C,C coupling, hydroxylation enzymology, and a metalloprotease with dual‐specificity.
Strunk E, Lobert A, Khorovich T, Guzman Lucio KM, Richarz R, Hohmann M, D'Agostino PM, Gulder TAM.   +7 more
europepmc   +2 more sources

Cryo-EM reveals an ensemble of cytochrome P450 reductase conformations in solution. [PDF]

Protein Sci
Abstract The eukaryotic electron transport system, mediated by cytochrome P450 reductase (CPR), plays a crucial role in driving myriads of reactions involved in the biosynthesis of physiologically active compounds (such as sterols, steroids, vitamins, and natural products), as well as in the metabolism of drugs, toxins, and carcinogens.
Lepesheva GI, Hargrove TY, Ren Y.
europepmc   +2 more sources

Selective Targeting of Human and Animal Pathogens of the Helicobacter Genus by Flavodoxin Inhibitors: Efficacy, Synergy, Resistance and Mechanistic Studies

International Journal of Molecular Sciences, 2021
Antimicrobial resistant (AMR) bacteria constitute a global health concern. Helicobacter pylori is a Gram-negative bacterium that infects about half of the human population and is a major cause of peptic ulcer disease and gastric cancer.
S. Salillas, J. Galano-Frutos, A. Mahía, R. Maity, María Conde-Giménez, Ernesto Anoz-Carbonell, Helena Berlamont, A. Velázquez‐Campoy, E. Touati, U. Mamat, U. Schaible, J. Gálvez, M. D. Díaz-de-Villegas, F. Haesebrouck, J. Aínsa, J. Sancho   +15 more
semanticscholar   +1 more source

The flavodoxin FldA activates the class Ia ribonucleotide reductase of Campylobacter jejuni

Molecular Microbiology, 2021
Campylobacter jejuni is a microaerophilic zoonotic pathogen with an atypical respiratory Complex I that oxidizes a flavodoxin (FldA) instead of NADH. FldA is essential for viability and is reduced via pyruvate and 2‐oxoglutarate oxidoreductases (POR/OOR).
Abdulmajeed Alqurashi, Laura Alfs, J. Swann, J. Butt, D. Kelly   +4 more
semanticscholar   +1 more source

Conformational dynamics of Escherichia coli flavodoxins in apo- and holo-states by solution NMR spectroscopy. [PDF]

PLoS ONE, 2014
Flavodoxins are a family of small FMN-binding proteins that commonly exist in prokaryotes. They utilize a non-covalently bound FMN molecule to act as the redox center during the electron transfer processes in various important biological pathways ...
Qian Ye, Yunfei Hu, Changwen Jin
doaj   +1 more source

Efficient hydroxylation of flavonoids by using whole-cell P450 sca-2 biocatalyst in Escherichia coli

Frontiers in Bioengineering and Biotechnology, 2023
The hydroxylation is an important way to generate the functionalized derivatives of flavonoids. However, the efficient hydroxylation of flavonoids by bacterial P450 enzymes is rarely reported.
Baodong Hu, Baodong Hu, Baodong Hu, Baodong Hu, Xinrui Zhao, Xinrui Zhao, Xinrui Zhao, Xinrui Zhao, Jingwen Zhou, Jingwen Zhou, Jingwen Zhou, Jingwen Zhou, Jianghua Li, Jianghua Li, Jianghua Li, Jianghua Li, Jian Chen, Jian Chen, Jian Chen, Jian Chen, Guocheng Du, Guocheng Du, Guocheng Du, Guocheng Du, Guocheng Du   +24 more
doaj   +1 more source

Thioredoxin reductase from Bacillus cereus exhibits distinct reduction and NADPH‐binding properties

FEBS Open Bio, 2021
Low‐molecular‐weight (low Mr) thioredoxin reductases (TrxRs) are homodimeric NADPH‐dependent dithiol flavoenzymes that reduce thioredoxins (Trxs) or Trx‐like proteins involved in the activation networks of enzymes, such as the bacterial class Ib ...
Marita Shoor, Ingvild Gudim, Hans‐Petter Hersleth, Marta Hammerstad   +3 more
doaj   +1 more source

Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae. [PDF]

PLoS ONE, 2012
Isoprenoids, which are a large group of natural and chemical compounds with a variety of applications as e.g. fragrances, pharmaceuticals and potential biofuels, are produced via two different metabolic pathways, the mevalonate (MVA) pathway and the 2-C ...
Siavash Partow, Verena Siewers, Laurent Daviet, Michel Schalk, Jens Nielsen   +4 more
doaj   +1 more source

A long-chain flavodoxin protects Pseudomonas aeruginosa from oxidative stress and host bacterial clearance. [PDF]

PLoS Genetics, 2014
Long-chain flavodoxins, ubiquitous electron shuttles containing flavin mononucleotide (FMN) as prosthetic group, play an important protective role against reactive oxygen species (ROS) in various microorganisms. Pseudomonas aeruginosa is an opportunistic
Alejandro J Moyano, Romina A Tobares, Yanina S Rizzi, Adriana R Krapp, Juan A Mondotte, José L Bocco, Maria-Carla Saleh, Néstor Carrillo, Andrea M Smania   +8 more
doaj   +1 more source