Results 61 to 70 of about 6,613 (229)

Tryptophan Suppresses FTH1‐Driven Ferritinophagy, a Key Correlate of Prognosis in Hepatocellular Carcinoma

open access: yesCell Proliferation, Volume 59, Issue 1, January 2026.
Intracellular tryptophan levels modulate selective autophagy of FTH1 via the NCOA4 pathway. This autophagic process then inhibits 6‐HMT synthesis, which then results in an increase in reactive oxygen species and ferroptosis. ABSTRACT Hepatocellular carcinoma (HCC) remains a lethal malignancy with limited therapeutic options.
Xinxiang Cheng   +10 more
wiley   +1 more source

Iron Deficiency Modulates Metabolic Landscape of Bacteroidetes Promoting Its Resilience during Inflammation

open access: yesMicrobiology Spectrum, 2023
Bacteria have to persist under low iron conditions in order to adapt to the nutritional immunity of a host. Since the knowledge of iron stimulon of Bacteroidetes is sparse, we examined oral (Porphyromonas gingivalis and Prevotella intermedia) and gut ...
Janina P. Lewis, Qin Gui
doaj   +1 more source

Structural insights for enhanced ROS detoxification of eKatE, a recently identified catalase in atypical E. coli

open access: yesThe FEBS Journal, Volume 293, Issue 1, Page 196-219, January 2026.
We revealed the crystal structure of eKatE from atypical E. coli. eKatE exhibits a hydrogen‐peroxide‐sensitive major channel, a stabilized dimeric interface, an unusual covalent bond between C392 and Y415, and other distinctive features. These structural features contribute to its enhanced catalase activity compared to KatE in typical E.
Eunhee Koh   +7 more
wiley   +1 more source

Biosynthese der Biphenomycine, einer Familie potenter Antibiotika

open access: yesAngewandte Chemie, Volume 137, Issue 51, December 15, 2025.
Der vollständige Biosyntheseweg der Biphenomycin‐Antibiotika wird aufgeklärt und offenbart eine einzigartige enzymatische Maschinerie mit einem bifunktionellen MNIO, einer regioselektiven Arginase, einem B12‐abhängigen rSAM für C,C‐Kupplung, Enzymen zur Hydroxylierung sowie einer zweifach spezifischen Metalloprotease.
Elisabeth Strunk   +7 more
wiley   +1 more source

3D Domain Swapping Dimerization of the Receiver Domain of Cytokinin Receptor CRE1 From Arabidopsis thaliana and Medicago truncatula

open access: yesFrontiers in Plant Science, 2021
Cytokinins are phytohormones regulating many biological processes that are vital to plants. CYTOKININ RESPONSE1 (CRE1), the main cytokinin receptor, has a modular architecture composed of a cytokinin-binding CHASE (Cyclases/Histidine kinases Associated ...
Linh H. Tran   +6 more
doaj   +1 more source

Redox potentials of algal and cyanobacterial flavodoxins [PDF]

open access: yesBiochemical Journal, 1984
The redox potentials of flavodoxins from the cyanobacteria Synechococcus PCC 6301 (formerly Anacystis nidulans) and Nostoc strain MAC, and from the red alga Chondrus crispus, were determined by potentiometric titration. For the oxidized-semiquinone interconversion the potentials at pH 7.0 of the three flavodoxins were between −210 and −235 mV, and ...
G A, Sykes, L J, Rogers
openaire   +2 more sources

Short-Range Electron Transfer in Reduced Flavodoxin: Ultrafast Nonequilibrium Dynamics Coupled with Protein Fluctuations.

open access: yesJournal of Physical Chemistry Letters, 2018
Short-range electron transfer (ET) in proteins is an ultrafast process on the similar time scales as local protein-solvent fluctuation, and thus the two dynamics are coupled.
Mainak Kundu   +4 more
semanticscholar   +1 more source

Crystallographic characterization of flavodoxin from Anacystis nidulans [PDF]

open access: yesJournal of Molecular Biology, 1975
Flavodoxin isolated from the blue-green alga, Anacystis nidulans, crystallizes from ammonium sulfate in space group P212121, with a = 57.08 A, b = 69.24 A and c = 45.55 A. The diffraction patterns extend to a resolution of at least 1.8 A. Reduction of the flavin mononucleotide in the crystalline protein, to either the semi-quinone or fully reduced ...
Smith, Ward W.   +4 more
openaire   +3 more sources

Pyruvate: Ferredoxin oxidoreductase is involved in IgA-related microbiota dysbiosis and intestinal inflammation

open access: yesFrontiers in Immunology, 2022
IntroductionInflammatory bowel diseases (IBDs) are associated with both immune abnormalities and dysbiosis, characterized by a loss of Faecalibacterium prausnitzii (F. prausnitzii). However, the reason for F.
Kairuo Wang   +23 more
doaj   +1 more source

Artificial Enzymatic Electrochemistry

open access: yesChemElectroChem, Volume 12, Issue 21, November 3, 2025.
Artificial enzymatic electrochemistry has emerged as an effective method to extend the catalytic abilities of enzymes. This review explores the bioelectrochemical methods used to understand and optimize the structure and function of artificial enzymes.
Nya E. Black   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy