Results 21 to 30 of about 35,991 (298)
Mutações no Estilo de Pensamento: Ludwik Fleck e o Modelo Biológico na Historiografia da Ciência
Revista de Filosofia Moderna e Contemporânea, 2018 O objetivo desse artigo é analisar, a partir da obra de Ludwik Fleck, o papel da biologia e das ciências da vida como matriz modelar na constituição de uma teoria e metodologia de escrita da história da ciência. O que aqui é chamado de “modelo biológico”
Mauro Lúcio Leitão Condé
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Ludwik Fleck e a presente história das ciências Ludwik Fleck and the history of science today
História, Ciências, Saúde: Manguinhos, 1994 O médico e epistemologista Ludwik Fleck desenvolveu, nas décadas de 1920-30, uma abordagem bastante original para o estudo das ciências. Ele apoiou sua epistemologia em duas bases: por um lado, em sua própria experiência profissional de bacteriologista e
Ilana Löwy
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Revista Brasileira de Pesquisa em Educação em Ciências, 2020 A perspectiva da sociologia do conhecimento do médico polonês Ludwik Fleck (1896–1961) vem ganhando destaque no meio acadêmico brasileiro nas últimas décadas e, em particular, na área de pesquisa em ensino de ciências.
André Ferrer Pinto Martins
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng +3 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
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Ludwik Fleck: a Philosopher Forgotten in Ukraine
Idei, 2020 Ludwik Fleck is a philosopher, biologist and physician who had a decisive influence on Thomas Kuhn. The research is dedicated to a publication of the Ukrainian translation of the Fleck’s main work “Genesis and Development of a Scientific Fact” by ...
Oleh Shepetiak, Оksana Shepetiak
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FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
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