Results 41 to 50 of about 35,991 (298)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Sociogênese do conhecimento e pesquisa em ensino: contribuições a partir do referencial Fleckiano
Caderno Brasileiro de Ensino de Física, 2002 O trabalho aborda a teoria do conhecimento de Ludwik Fleck, analisando as origens e o contexto que orientaram sua produção, desde o contato com a Escola Polonesa de Filosofia da Medicina.
Demétrio Delizoicov +4 more
doaj
Tadeusz Bilikiewicz’s Background in the Debate with Ludwik Fleck
Transversal: International Journal for the Historiography of Science, 2016 One of the factors that adversely influenced the worldwide reception of Fleck was the rather narrow critical interest that his ideas had aroused in Poland.
Artur Koterski
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Wachstum in der Klimawissenschaft: Ein blinder Fleck [PDF]
, 2018 WACHSTUM IN DER KLIMAWISSENSCHAFT: EIN BLINDER FLECK Wachstum in der Klimawissenschaft: Ein blinder Fleck / Kuhnhenn, Kai (CC BY-NC-ND) (-
Kuhnhenn, Kai
core
Identification of the agent of grapevine fleck disease [PDF]
, 2015 An antiserum against an Italian isolate of grapevine phloem-limited isometric virus (GPLIV) was used in an ELISA survey carried out for assessing the natural distribution of the virus and its association with fleck disease.
Boscia, D. +3 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
D-MELD does not predict post-liver transplantation survival: a single-center experience from Brazil
Annals of Hepatology, 2014 Background. The D-MELD score was designed to prevent donor-recipient matches with a high risk of unfavorable outcome. The main objective of the present study was to assess the predictive value of the D-MELD score for 1-month and 3-month post-transplant ...
Ane M. Costabeber +5 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source