Results 51 to 60 of about 33,295 (296)

D-MELD does not predict post-liver transplantation survival: a single-center experience from Brazil

Annals of Hepatology, 2014
Background. The D-MELD score was designed to prevent donor-recipient matches with a high risk of unfavorable outcome. The main objective of the present study was to assess the predictive value of the D-MELD score for 1-month and 3-month post-transplant ...
Ane M. Costabeber, Lívia C. Lionço, Cláudio Marroni, Maria L. Zanotelli, Guido Cantisani, Ajácio Brandão, M.D., Ph.D.   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Alogliptin after acute coronary syndrome in patients with type 2 diabetes.

New England Journal of Medicine, 2013
BACKGROUND To assess potentially elevated cardiovascular risk related to new antihyperglycemic drugs in patients with type 2 diabetes, regulatory agencies require a comprehensive evaluation of the cardiovascular safety profile of new antidiabetic ...
W. White, C. Cannon, S. Heller, S. Nissen, R. Bergenstal, G. Bakris, Alfonso T. Perez, P. Fleck, Cyrus Mehta, S. Kupfer, C. Wilson, W. Cushman, F. Zannad   +12 more
semanticscholar   +1 more source

Alexander Fleck, Baron Fleck of Saltcoats, 1889-1968 [PDF]

Biographical Memoirs of Fellows of the Royal Society, 1971
Abstract Lord Fleck who died in London on 6 August 1968 was most widely known as a distinguished leader in chemical industry and as Chairman of Imperial Chemical Industries Ltd from 1953 to 1960. It was very apparent, however, to all with a closer acquaintance with him, that he could have been just as successful in other fields.
openaire   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Uma leitura da epistemologia de Ludwik Fleck: possíveis aproximações com o marxismo

Alexandria
Este trabalho, de caráter teórico, tem como objetivo buscar por aproximações entre o marxismo e a epistemologia de Ludwik Fleck, identificando pontos de convergências e divergências entre eles.
Marllon Moreti de Souza Rosa, Mariana Aparecida Bologna Soares de Andrade   +1 more
doaj   +1 more source

Fleck:

Transversal: International Journal for the Historiography of Science
On at least two occasions, Thomas Kuhn referred to Ludwik Fleck. He did it in the Preface to The Structure of Scientific Revolutions, and years later in the introduction to the English translation of Fleck’s work. On the first occasion, he states that Fleck “anticipated many of my own ideas”, but he did not specify which.
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Ludwik Fleck: pesquisador e prisioneiro

Arquivo Maaravi: Revista Digital de Estudos Judaicos da UFMG, 2012
Quando o objetivo único de médicos e autoridades é desenvolver a ciência sem levar em conta os seres humanos, todos os caminhos ficam abertos para qualquer deformação, todas as regressões e degradações da desumanização tornam-se possíveis.
Ethel Mizrahy
doaj   +1 more source