Results 51 to 60 of about 1,192,052 (317)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Budownictwo i Architektura, 2013 Simplified methodology helpful in a reliable specification of moment - rotation dependences characterizing the steel beam-to-column joint flexibility under fully developed fire conditions is presented and discussed in detail.
Mariusz Maślak, Małgorzata Snela
doaj +1 more source
CoRR, 2013 The development of new methods and representations for temporal decision-making requires a principled basis for characterizing and measuring the flexibility of decision strategies in the face of uncertainty. Our goal in this paper is to provide a framework - not a theory - for observing how decision policies behave in the face of informational ...
Tom Chávez, Ross D. Shachter
openaire +3 more sources
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
An attribute approach to the measurement of manufacturing system flexibility [PDF]
An uncertain environment has forced manufacturing systems to have flexibility. Uncertainties involved with internal and external factors means that flexibility becomes an important competitive factor for the firms.
Chang, An-Yuan
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Music-induced cognitive change and whole-brain network flexibility: a pilot study
Frontiers in NeuroscienceIntroductionCognitive impairment that exceeds age-related cognitive decline is a risk factor for Alzheimer’s disease and related dementias. As the older adult population is notably increasing every year, significant efforts are being made to preserve ...
E. Lydia Wu-Chung +11 more
doaj +1 more source
Net Load Carrying Capability of Generating Units in Power Systems
Energies, 2017 This paper proposes an index called net load carrying capability (NLCC) to evaluate the contribution of a generating unit to the flexibility of a power system.
Chang-Gi Min, Mun-Kyeom Kim
doaj +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source