Results 51 to 60 of about 747,837 (268)
Music-induced cognitive change and whole-brain network flexibility: a pilot study
Frontiers in NeuroscienceIntroductionCognitive impairment that exceeds age-related cognitive decline is a risk factor for Alzheimer’s disease and related dementias. As the older adult population is notably increasing every year, significant efforts are being made to preserve ...
E. Lydia Wu-Chung +11 more
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Net Load Carrying Capability of Generating Units in Power Systems
Energies, 2017 This paper proposes an index called net load carrying capability (NLCC) to evaluate the contribution of a generating unit to the flexibility of a power system.
Chang-Gi Min, Mun-Kyeom Kim
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Old and new forms of communication between the state and society on the way to a new social contract
RUDN journal of SociologyThe article considers the concept of social contract as a consensus between the state and the people. Based on the works of T. Hobbes, D. Locke, J.-J. Rousseau, C. Montesquieu, German social thought, in the context of reflections on the “legitimacy” of R.
R. I. Anisimov
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Journal of Interventional Epidemiology and Public HealthIntroduction: Human immunodeficiency virus (HIV) infection is still a global public health problem. The number of HIV-positive individuals was estimated to be 38.0 million worldwide in 2020, with 2.78 million being children and adolescents aged 0 to 19 ...
Peter Richard Torokaa +10 more
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Space Governance Analysis as a Product of Multi-Actors Communication and Through the Lens of Systems Feedback Loops [PDF]
Advanced Space LawThis article explores the evolving architecture of space governance, highlighting a shift from rigid, abstract legal frameworks to more dynamic, context-sensitive mechanisms.
Anna Hurova
doaj +1 more source
CoRR, 2013 The development of new methods and representations for temporal decision-making requires a principled basis for characterizing and measuring the flexibility of decision strategies in the face of uncertainty. Our goal in this paper is to provide a framework - not a theory - for observing how decision policies behave in the face of informational ...
Tom Chávez, Ross D. Shachter
openaire +3 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source