Results 51 to 60 of about 789,615 (268)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Brain, 2016 This scientific commentary refers to ‘Neural, electrophysiological and anatomical basis of brain-network variability and its characteristic changes in mental disorders’ by Zhang et al. (doi:10.1093/aww143). The vastness of the brain’s dynamic repertoire is one of the remarkable features of brain function, making it possible to adapt rapidly and ...
Marcelo G, Mattar +2 more
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
16 – 18 YAŞ GRUBU FUTBOLCULARDA MASAJIN ESNEKLİK ÜZERİNE ETKİSİ
Spormetre Beden Eğitimi ve Spor Bilimleri Dergisi, 2005 Bu araştırmanın amacı 16 – 18 yaş grubu futbolcularda masajın esnekliğe etkisinin incelenmesidir. Bu araştırmaya katılan denekler, Gençlerbirliği spor kulübü genç takımında futbol oynayan 16 – 18 yaş grubunda erkek sporculardan seçilmiştir.
Yağmur Akkoyunlu +2 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Budownictwo i Architektura, 2013 Simplified methodology helpful in a reliable specification of moment - rotation dependences characterizing the steel beam-to-column joint flexibility under fully developed fire conditions is presented and discussed in detail.
Mariusz Maślak, Małgorzata Snela
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source