Results 61 to 70 of about 747,837 (268)

İşletmelerde Esnek Üretim Sistemlerinin, Maliyet Unsurları Üzerindeki Etkisi

Selçuk Üniversitesi Sosyal Bilimler Meslek Yüksekokulu Dergisi, 2017
Günümüzde, işletmelerin verimliliklerinin arttırılmasında, teknolojideki değişimlere uyum sağlamak büyük önem arz etmektedir. Müşteri istek ve ihtiyaçlarının sürekli değiştiği rekabet koşulları, işletmelerin üretim ortamlarını daha esnek hale ...
Servet Say, Fırat Kınalı
doaj  

Reliability of Standardised High-Intensity Static Stretching on the Hamstrings over Multiple Visits

Muscles
Static stretching (SS) is commonly used in athletic programs, and the intensity of SS has recently been examined for its effects on range of motion (ROM), strength and passive stiffness.
Joseph Bryant, Darren J. Cooper, Derek M. Peters, Matthew D. Cook   +3 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Surf’s Up for Postural Stability: A Descriptive Study of Physical Activity, Balance, Flexibility, and Self-Esteem in Healthy Adults

Journal of Functional Morphology and Kinesiology
Background: This study examines balance, flexibility and self-esteem among healthy individuals who engage in surfing compared to those who do not surf. Methods: A cross-sectional study design was conducted with 124 participants divided into the following
Guillermo De Castro-Maqueda, Miguel Ángel Rosety-Rodríguez, Macarena Rivero-Vila, Jorge Del Rosario Fernández-Santos, Teppei Abiko   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The investigation of the effects of the sports goalball on the level of some physical propriety of visually handicapped individuals

Türk Spor ve Egzersiz Dergisi, 2015
This study was carried out with the aim of stating whether or not playing goalball is effective on the duration of aural reaction, the power of hand and grasping, flexibility and balance of the individuals those visually disabled in different degrees ...
Ersin Arslan, H. Bayram Temur, İsrafil Aslan, Mahmut Aktı   +3 more
doaj  

Choosing the Trailer Bus Train Scheme According to Fuel Economy Indicators

Vehicles
The presented research is focused on the development of the bus rapid transit (BRT) system, combining the high capacity of rail transport with the flexibility of bus routes.
Oleksandr Kravchenko, Volodymyr Sakhno, Anatolii Korpach, Oleksii Korpach, Ján Dižo, Miroslav Blatnický   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Flexible Switch Capacitor Circuit Suitable for Flexible Wearable Devices

南方能源建设
[Objective] Stable and high-quality power supply and bendability of flexible wearable devices are the current development needs of flexible wearable devices.
Ting YANG, Liye TIAN, Lei YANG, Yuenong YANG, Yangyang XIE   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source