Results 61 to 70 of about 1,192,052 (317)

Old and new forms of communication between the state and society on the way to a new social contract

RUDN journal of Sociology
The article considers the concept of social contract as a consensus between the state and the people. Based on the works of T. Hobbes, D. Locke, J.-J. Rousseau, C. Montesquieu, German social thought, in the context of reflections on the “legitimacy” of R.
R. I. Anisimov
doaj   +1 more source

Workplace Flexibility 2010 Staff & Consultants

, 2011
Staff and consultants biographies for the event: What an Aging Workforce Can Teach Us About Workplace Flexibility held on July 18, 2005 by Workplace Flexibility ...
Workplace Flexibility 2010, Georgetown University Law Center
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Evaluation of the Human Immunodeficiency Virus viral load surveillance system, national perspective in Tanzania: A descriptive cross-sectional study

Journal of Interventional Epidemiology and Public Health
Introduction: Human immunodeficiency virus (HIV) infection is still a global public health problem. The number of HIV-positive individuals was estimated to be 38.0 million worldwide in 2020, with 2.78 million being children and adolescents aged 0 to 19 ...
Peter Richard Torokaa, Loveness John Urio, Ambwene Mwakalobo, Alex Sifaeli Magesa, James Njoroge Allan, David John Osima, Focus Medard Shao, Joseph Mziray, Yulitha Barnabas, Agricola Joachim, Mtebe Majigo   +10 more
doaj   +1 more source

Space Governance Analysis as a Product of Multi-Actors Communication and Through the Lens of Systems Feedback Loops [PDF]

Advanced Space Law
This article explores the evolving architecture of space governance, highlighting a shift from rigid, abstract legal frameworks to more dynamic, context-sensitive mechanisms.
Anna Hurova
doaj   +1 more source

Appendix A: Definition of Workplace Flexibility

, 2008
A definition of Workplace Flexibility from the event: Senate Special Committee on Aging Hearing held April 30, 2008 for Workplace Flexibility ...
Workplace Flexibility 2010, Georgetown University Law Center
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

İşletmelerde Esnek Üretim Sistemlerinin, Maliyet Unsurları Üzerindeki Etkisi

Selçuk Üniversitesi Sosyal Bilimler Meslek Yüksekokulu Dergisi, 2017
Günümüzde, işletmelerin verimliliklerinin arttırılmasında, teknolojideki değişimlere uyum sağlamak büyük önem arz etmektedir. Müşteri istek ve ihtiyaçlarının sürekli değiştiği rekabet koşulları, işletmelerin üretim ortamlarını daha esnek hale ...
Servet Say, Fırat Kınalı
doaj  

Reliability of Standardised High-Intensity Static Stretching on the Hamstrings over Multiple Visits

Muscles
Static stretching (SS) is commonly used in athletic programs, and the intensity of SS has recently been examined for its effects on range of motion (ROM), strength and passive stiffness.
Joseph Bryant, Darren J. Cooper, Derek M. Peters, Matthew D. Cook   +3 more
doaj   +1 more source