Results 71 to 80 of about 747,837 (268)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
The unfitness of dwellings: why spatial and conceptual boundaries matter
Buildings & CitiesThe boundaries of work and home are constantly evolving. Working from home challenges the prevailing understandings of what a home is supposed to be and do, and what work is.
Essi Nisonen +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
A Point-Theory of Morphogenesis
MathematicsBuilding on earlier work with generalised conic sections, we use the superformula to introduce ultra-flexibility instead of rigidity as encoded in the geometry of Euclid and Descartes.
Johan Gielis
doaj +1 more source
Ethics & Global Politics, 2013 How can advocates of global democracy grapple with the empirical conditions that constitute world politics? I argue that flexibility mechanisms—;commonly used to advance international cooperation—should be employed to make the institutional design ...
Jonathan W. Kuyper
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Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Impact of warm-up methods on strength-speed for sprinters in athletics: a mini review
Frontiers in Sports and Active LivingIn athletics, achieving peak performance during competitions is crucial. Warm-up strategies play a crucial role in optimizing the strength-speed performance of sprinters in athletics, especially tailored to the physiological demands of speed events.
Eduardo Herrera +2 more
doaj +1 more source
, 2021 Recursive definitions of predicates by means of inference rules are ubiquitous in computer science. They are usually interpreted inductively or coinductively, however there are situations where none of these two options provides the expected meaning. In the thesis we propose a flexible form of coinductive interpretation, based on the notion of corules,
openaire +2 more sources