Results 61 to 70 of about 3,280,790 (318)
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
ChildrenBackground/Objectives: The presence of a child with special educational needs (SENs) necessitates that both the child and their family engage in adaptive processes and develop resilience in response to the developmental challenges that arise following an
Sandra Figueiredo, Raquel Pereira
doaj +1 more source
Modeling and Simulation of a Flexible Manufacturing System—A Basic Component of Industry 4.0
Applied Sciences, 2020 The field of Flexible Manufacturing Systems (FMS) has seen in recent years a dynamic development trend and can now be considered an integral part of intelligent manufacturing systems and a basis for digital manufacturing.
Adriana Florescu, Sorin Adrian Barabas
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Frontiers in PsychiatryIntroductionsEmotion regulation, depressive symptoms and mental imagery have both been linked to alcohol use disorder (AUD). However, the association between these factors have not been investigated within a group of individuals with AUD.ObjectivesThe ...
M. Rydzewska +9 more
doaj +1 more source
Telework in the Federal Government: The Overview Memo [PDF]
, 2009 Flexible Work Arrangements (FWAs) alter the time and/or place that employees work on a regular basis in a manner that is manageable and predictable for both employees and employers.1 Telework, also called telecommuting, refers to an FWA that enables an ...
Workplace Flexibility 2010, Georgetown University Law Center
core +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Active assessment of fitness and performance in a general population
Frontiers in Sports and Active LivingMuch of the current worldwide morbidity results largely from unhealthy diet, inactivity, and inadequate access to health resources. Improving body composition, strength, endurance, and cardiorespiratory fitness is associated with increased longevity and ...
Brent Winslow +5 more
doaj +1 more source
Phased Retirement Data Sheet [PDF]
, 2010 This data sheet includes information on current coverage and participation by American workers in pension and retirement plans. It also includes information on what employees say they want in terms of flexible work arrangements and access to pension and ...
Workplace Flexibility 2010, Georgetown University Law Center
core +1 more source