Results 71 to 80 of about 3,280,790 (318)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Agenda [PDF]

open access: yes, 2006
The agenda of the Workers with Disabilities: The Role of Workplace Flexibility event held November 13 ...
Workplace Flexibility 2010, Georgetown University Law Center
core   +1 more source

Flyer [PDF]

open access: yes, 2011
The flyer of the Meeting the Needs of Today’s Families: The Role of Workplace Flexibility event held May 1 ...
Workplace Flexibility 2010, Georgetown University Law Center
core   +3 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Valuing deliberate built-in flexibility in houses – exampled

open access: yesInternational Journal of Strategic Property Management, 2018
People’s Housing requirements commonly transition over time, and there are financial, social and environmental impacts associated with altering and moving houses.
David G. Carmichael, Reza Taheriattar
doaj   +1 more source

FMLA Leave Determinations/Medical Certifications [PDF]

open access: yes, 2007
Part one of this memorandum provides a summary of questions asked and comments submitted in response to the DOL request for information ( RFI ) about FMLA leave determinations and medical certifications.
Workplace Flexibility 2010, Georgetown University Law Center
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Resources for Workplace Flexibility, Families and Child Development [PDF]

open access: yes, 2011
A list of resources for Workplace Flexibility, Families and Child ...
Workplace Flexibility 2010, Georgetown University Law Center
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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