Results 31 to 40 of about 21,652 (255)

Modeling and Nonlinear Dynamic Characteristics Analysis of Fault Bearing Time-Varying Stiffness-Flexible Rotor Coupling System

open access: yesMathematics
There is a complex dynamic interaction between the aero-engine bearing and the rotor, and the resulting time-varying system parameters have an impact on the nonlinear dynamic characteristics of the rolling bearing-flexible rotor system.
Renzhen Chen   +5 more
doaj   +1 more source

Carbon dioxide rebreathing caused by deformed silicon leaflet in the expiratory unidirectional valve

open access: yesJournal of Anaesthesiology Clinical Pharmacology, 2013
Rebreathing of carbon dioxide caused by incompetent ′cage and disc′ unidirectional valves has been reported earlier. Some manufacturers have changed the design of unidirectional valves to ′flexible leaflets′.
Arumugam Vasudevan   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Stresses and Displacements in an Elliptically Perforated Circular Disc Under Radial Pressure

open access: yesEngineering Transactions, 2014
The complex potentials governing the elastic equilibrium of a finite circular disc, elliptically perforated at its center, are obtained using Muskhelishvili’s formulation.
Christos F. MARKIDES   +1 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

NATURAL FREQUENCIES OF TUNED AND MISTUNED BLADED DISCS ON A SHAFT

open access: yesTASK Quarterly, 2006
The dynamic behaviour of a rotor consisting of two tuned and mistuned bladed discs on a solid shaft is considered. The effect of the shaft’s flexibility on the dynamic characteristics of the bladed discs and the coupling effects between the shaft and ...
ROMUALD RZĄDKOWSKI   +2 more
doaj  

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Disc-Pole Assignment for Robust Control of Flexible Structures.

open access: yesTRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C, 1999
This paper presents a method of disc-pole assignment for the design of robust control of flexible structures. The proposed method achieves a pole assignment of the controlled modes to a specified circular region in the complex plane and simultaneously obtains robust stability of the closed-loop system for important residual modes.
OKUBO, Hiroshi, ZENIYA, Susumu
openaire   +2 more sources

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

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