Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Dual-band flexible metamaterial absorber working in 5G band
AIP AdvancesThis article presents a thin and flexible artificial electromagnetic absorber with two absorption peaks at frequencies of 28 and 39 GHz for 5G communication.
Jianfei Zhu, Guoliang Gao, Weien Lai
doaj +1 more source
Impact of social capital on flexible work organisation models: comparative study of european countries [PDF]
The present economic context is heavily marked by a global crisis without precedents. Facing this constraint, companies feel pressured to undertake even greater efforts in order to optimize available resources.
Ferreira, Pedro +2 more
core +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Transitional Labour Markets, from theory to policy application. Can transitional labour markets contribute to a less traditional gender division of labour ? [PDF]
Much of the gender inequality in the labour market is brought about by women's dual role as worker and (potential) carer. In this regard transitional arrangements can contribute to mitigate the risks associated with parenthood and to distribute risks ...
Janine Leschke, Maria Jepsen
core
Determining the research status and coronavirus anxiety scores of academics during the flexible working arrangements initiated after the COVID-19 pandemic. [PDF]
J Taibah Univ Med Sci, 2021 Akyildiz D, Durna S.
europepmc +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
EU Enlargement, Migration and the New Constitution [PDF]
The paper deals with the effects of migration resulting from EU Eastern enlargement on the welfare states of Western Europe. Although migration is good in principle, as it yields gains from trade and specialization for all countries involved, it does so ...
Hans-Werner Sinn
core
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
A greedy heuristic approach for the project scheduling with labour allocation problem [PDF]
, 2012 Responding to the growing need of generating a robust project scheduling, in this article we present a greedy algorithm to generate the project baseline schedule. The robustness achieved by integrating two dimensions of the human resources flexibilities.
Attia, El-Awady +2 more
core