Results 91 to 100 of about 1,888,940 (309)

What is the Evolution of Flexible Work in Corporations and What are the Key Trends? [PDF]

, 2017
[Excerpt] Around the world, especially in North America and Europe, businesses are exploring and embracing new ways of bringing flexibility to the workplace.
Chiang, Joey, Lundgren, Andrew
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

More Pay and Benefits or Better Work-life Balance? Post Pandemic Perspectives on Employee Centricity among University Frontline Staff

Journal on Efficiency and Responsibility in Education and Science
The COVID-19 pandemic forced organisations across diverse industries to redraw their business models globally. Businesses crumbled, downsized, lay off workers, streamlined and digitalized their workflow, maintaining skeletal staff to support integral ...
Phillip Dangaiso, Divaries Cosmas Jaravaza, Paul Mukucha, Audrey Bowora, Gaylord Hlabiso, Knowledge Jonasi   +5 more
doaj   +1 more source

NEW PATTERNS IN SCHEDULING WORKING TIME [PDF]

Flexible work arrangements should focus on providing employees with more options for when and how they do their work. Organizations can provide a suite of flexible options to enable employees to choose the arrangements that best balance their work with ...
Catalina Soriana SITNIKOV, Claudiu George BOCEAN   +1 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Flextime/Flexspace for All in the Organization? A Study of the Availability, Use, and Consequences of Flexible Work Arrangements for Low and High SES Employees in Nine European Countries

Social Sciences
This article investigates the relationship between employee socioeconomic status (SES) and the availability, use, and consequences for employees of flexible work arrangements (working from home and flexible starting and finishing times).
Tanja van der Lippe, Laura den Dulk, Katia Begall   +2 more
doaj   +1 more source

TeamWorker: An agent-based support system for mobile task execution [PDF]

, 2005
Traditional workflow management systems are considered insufficiently flexible to support autonomous job management via close team working. This paper proposes a multi-agent system approach to enhancing existing workflow management systems to enable team-
Lee, H, Mihailescu, P, Shepherdson, J
core  

Refinements of the holonomic approximation lemma

, 2017
The holonomic approximation lemma of Eliashberg and Mishachev is a powerful tool in the philosophy of the $h-$principle. By carefully keeping track of the quantitative geometry behind the holonomic approximation process, we establish several refinements ...
Alvarez-Gavela, Daniel
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source