Results 81 to 90 of about 1,888,940 (309)

A Flexible Simple Thermostat for Small Objects and the Range of 100 to 400 K [PDF]

, 1970
A flexible, inexpensive thermostat for the temperature range 100 to 400 K is described. Liquid nitrogen is the coolant and a gas serves as transfer medium.
Bilger, H. R., Nicolet, M.-A.
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Engaging men in flexible working arrangements [PDF]

This paper highlights that men want more flexibility at all stages of their career and they perform better when they have it.  We also know a large number of men have considered leaving their current employer due to a lack of flexibility.

core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Flexible Working and Performance: A Systematic Review of the Evidence for a Business Case [PDF]

, 2011
Interest in the outcomes of flexible working arrangements dates from the mid 1970s, when researchers attempted to assess the impact of flexitime on worker performance.
Akerlof, Alis, Allen, Allen, Almer, Anderson, Anderson, Ashford, Atkinson, Bailey, Bailyn, Baltes, Baptiste, Batt, Beauregard, Bertolini, Bielenski, Blau, Blettner, Bloom, Boles, Bond, Boxall, Branine, Brough, Brown, Burke, Campbell-Clark, Caprioni, Casper, Centre for Reviews and Dissemination, Chartered Institute of Personnel and Development, Chow, Christensen, Cooke, Cooper-Hakim, Costa, Costa, Cranfield School of Management, Dalton, De Cieri, Department for Work and Pensions, Dex, Dex, Dex, Di Martino, Dodd, DTI, Dunham, Eaton, Eby, European Commission, Facer, Fisher, Fleetwood, Forsyth, Foster Thompson, Fotini, Frank, Friedman, Frye, Fullin, Gajendran, Glass, Glass, Golden, Golden, Golembiewski, Golembiewski, Goodstein, Goodstein, Gray, Greene, Gregory, Gropel, Grover, Hackman, Halpern, Hannah, Harley, Harrick, Harris, Harter, Harvey, Healy, Hill, Hill, Hill, Hogarth, Hohl, Hooker, Hughes, Hyland, Johnson, Karasek, Karasek, Karatepe, Kauffeld, Kelliher, Kelliher, Kelly, Kelly, Kersley, Kim, Konrad, Kopleman, Kossek, Kossek, Kossek, Krausz, Kraut, Kurland, Lapierre, Latack, Lautsch, Lewis, Lewis, Lewis, Lodahl, Macky, Macky, Madsen, Madsen, Martinez-Sanchez, Martinez-Sanchez, Martinez-Sanchez, Maxwell, McCampbell, Meyer, Meyer, Mohr, Moon, Moore, Muthén, Nadeem, Narayanan, NHS Centre for Reviews and Dissemination, Nollen, O'Reilly, Orpen, Ortega, Paauwe, Paoli, Pierce, Pierce, Pierce, Purcell, Purcell, Rainey, Redman, Rogier, Romaine, Ronen, Ronen, Ronen, Ronen, Rothausen, Rothbard, Sands, Scandura, Schaufeli, Schein, Schmidt, Shamir, Shankar, Shepard, Shinn, Shockley, Skyrme, Sparks, Staples, Stavrou, Takeuchi, Thomas, Thompson, Tietze, Tomlinson, Tranfield, Trent, Vega, Venne, Verbakel, Virick, Wall, Wall, Wallace, Wang, Warr, White, Whitehouse, Wiley, Wise, Wood, Wood, Wood, Yanadori, Zeytinoglu, Zwahlen   +197 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Flexibility through working time accounts : reconciling economic efficiency and individual time requirements [PDF]

This paper discusses the tension between the demands of economic efficiency, on the one hand, and non-economic ends (leisure, family, etc.) on the other.
Seifert, Hartmut
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source