Results 91 to 100 of about 245,655 (314)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

The effect of total knee arthroplasty on joint movement during functional activities and joint range of motion with particular regard to higher flexion users

, 2005
Study aimed to evaluate active and functional knee excursion of patients before and after total knee arthroplasty (TKA) and to determine whether TKA restores quality of life related to functional activities of daily living. Found that although TKA offers
Nutton, R.W., Rowe, P.J., Myles, C M, Rowe, P J, Myles, C.M., Nutton, R   +5 more
core  

An isovelocity dynamometer method to determine monoarticular and biarticular muscle parameters [PDF]

, 2012
This study aimed to determine whether subject-specific individual muscle models for the ankle plantar flexors could be obtained from single joint isometric and isovelocity maximum torque measurements in combination with a model of plantar flexion ...
Yeadon, MR, King, MA, Forrester, SE, Conceição, F, Lewis, MGC   +4 more
core  

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Design and mechanical evaluation of a novel dynamic growth rod to improve the surgical treatment of early-onset scoliosis

Bone & Joint Research
Aims: Growth rods are the gold standard for treating early-onset scoliosis (EOS), but current treatments often fail to optimally promote spinal growth and require frequent distraction surgeries, leading to complications and significant burdens on ...
Yangyang Xu, Xueqing Wu, Da Lu, Yong Wu, Heng Li, Baoqing Pei   +5 more
doaj   +1 more source

Influence of Different Head and Neck Positions on Oropharyngeal Leak Pressure with the LMA Protector Airway: A Cross-over Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: The assessment of seal pressure or leak pressure in supraglottic devices has commonly been used to confirm device functionality and for research purposes regarding laryngeal mask airways (LMAs). When used for controlled ventilation, the LMA
Deepika, Ravipati Prafulla, Susheela Taxak, Vasudha Govil, Anushmita Lallar, Elizabeth James   +5 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Effect of weight around ankle on decreasing hip flexion excursion during gait in children with diplegia

Introduction Children with diplegia have considerably larger hip flexion excursion during the gait cycle than normal developing children. There have been few studies that look at the effect of ankle loading on gait in children with hemiparesis, but none ...
Nahla M. Ibrahim, Mai Elsayed Abbass
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

A substantial proportion of subjects with adolescent idiopathic scoliosis display spinal and peripheral proprioceptive deficits

Bone & Joint Open
Aims: Adolescent idiopathic scoliosis (AIS) is considered a multifactorial disease, and proprioceptive deficit (PD) is evident as a potential associated factor.
Kenney Ki Lee Lau, Kenny Yat Hong Kwan, Jason Pui Yin Cheung, Karlen Ka Pui Law, Arnold Yu Lok Wong, Daniel Hung Kay Chow, Kenneth Man Chee Cheung   +6 more
doaj   +1 more source