Results 91 to 100 of about 387,042 (307)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Pre- and Post-alpha Motoneuronal Control of the Soleus H-reflex during Sinusoidal Hip Movements in Human Spinal Cord Injury [PDF]

, 2006
The aim of this study was to establish the contribution of hip-mediated sensory feedback to spinal interneuronal circuits during dynamic conditions in people with incomplete spinal cord injury (SCI).
Chaudhuri, Debjani, Kay, Elizabeth, Knikou, Maria, Schmit, Brian D.   +3 more
core   +2 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Functional analysis of regenerated digit in newt following complete amputation at proximal interphalangeal joint

Journal of Biomechanical Science and Engineering
Amphibians possess high regeneration capacity of complicated structures such as articular joints. However, it is unknown when and how the joint function recovers during the regeneration process following a joint amputation. The present study examined the
Takeshi KASAHARA, Machiko TERAMOTO, Kiyokazu AGATA, Jeonghyun KIM, Takeo MATSUMOTO, Eijiro MAEDA   +5 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

How reliable are surgeons at assessing soft-tissue laxities in robotic arm-assisted total knee arthroplasty?: a prospective, multicentre surgeon-blinded study

Bone & Joint Open
Aims: Regardless of one’s alignment philosophy and belief in ligament releases, the precise estimation of soft-tissue laxities is crucial in total knee arthroplasty (TKA).
James A. Corbett, Darren B. Chen, Price Gallie, Anthony Leong, Jonathan S. Mulford, David Penn, Jil A. Wood, Samuel J. MacDessi   +7 more
doaj   +1 more source

The effects of rotator cuff tear on shoulder proprioception [PDF]

, 2019
Purpose: To evaluate the effects of rotator cuff tear (RCT) and its severity on shoulder proprioception. Methods: We studied 132 consecutive patients (67 M-65 F; mean age ± SD, 66.03 ± 9.04; range, 43–78) who underwent arthroscopic rotator cuff repair ...
Camerota, Filippo, Candela, Vittorio, Celletti, Claudia, Gumina, Stefano, Venditto, Teresa   +4 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Influence of Different Head and Neck Positions on Oropharyngeal Leak Pressure with the LMA Protector Airway: A Cross-over Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: The assessment of seal pressure or leak pressure in supraglottic devices has commonly been used to confirm device functionality and for research purposes regarding laryngeal mask airways (LMAs). When used for controlled ventilation, the LMA
Deepika, Ravipati Prafulla, Susheela Taxak, Vasudha Govil, Anushmita Lallar, Elizabeth James   +5 more
doaj   +1 more source