Results 81 to 90 of about 282,231 (302)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

The Impact of spinopelvic and hip mobility on passive hip flexion range of motion assessment [PDF]

Background Measuring passive hip flexion range of motion (ROM) is challenging due to compensatory movements. Despite the interest in using functional lateral radiographs for assessing hip mobility, the relationship with passive hip flexion ROM remains
VERGARI, Claudio, TAKEMOTO, Mitsuru, KIM, Youngwoo, TADA, Hiroshi, TOKUYASU, Hiroyuki, TSUSHIMA, Eiki   +5 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Goniometria dos membros pélvicos de pacas (Cuniculus paca) criadas em cativeiro Goniometry of the hind limbs of pacas (Cuniculus paca) raised in captivity

Pesquisa Veterinária Brasileira, 2009
O trabalho teve por objetivo avaliar por meio de estudos goniométricos os membros pélvicos de pacas criadas em cativeiro. Foram utilizadas oito pacas (Cuniculus paca), sendo três fêmeas e cinco machos, com peso entre 6,0 kg e 8,2 kg, nos quais foi ...
Fábio André Pinheiro de Araújo, Sheila Canevese Rahal, Márcia Rita F. Machado, Carlos Roberto Teixeira, Silvia Elaine R. de Sá Lorena, Luciano Barbosa   +5 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Tunnel combinations that should be avoided in anterior cruciate ligament reconstruction: a biomechanical assessment of 15 different combinations of femoral and tibial graft tunnels

Bone & Joint Open
Aims: Structured knowledge on the combined effect of various positions of femoral and tibial tunnels in reconstruction of the anterior cruciate ligament (ACL) on knee range of motion, rotatory stability, and anterior translatory laxity is limited.
Salameh Eljaja, Jørgen Tranum-Jensen, Mette Tavlo, Volkert Siersma, Michael Rindom Krogsgaard   +4 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Flexion and anterior knee pain after high flexion posterior stabilized or cruciate retaining knee replacement

, 2015
Background: Special high-flexion prosthetic designs show a small increase in postoperative flexion compared to standard designs and some papers show increased anterior knee pain with these prosthesis.Methods: A prospective double blind randomized ...
van de Groes, Sebastiaan; RadboudUMC Department of Orthopaedics Orthopaedic Research Laboratory University Medical Centre Nijmegen Nijmegen, The Netherlands, Koëter, Sander; Department of Orthopaedics Canisius Wilhelmina Ziekenhuis Nijmegen, The Netherlands, Verdonschot, Nico; RadboudUMC Department of Orthopaedics Orthopaedic Research Laboratory University Medical Centre Nijmegen Nijmegen, The Netherlands Department CTW Laboratory for Biomechanical Engineering University of Twente Enschede, The Netherlands, van der Ven, Paul; RadboudUMC Department of Orthopaedics Orthopaedic Research Laboratory University Medical Centre Nijmegen Nijmegen, The Netherlands, Kreemers - van de Hei, Keetie; Department of Orthopaedics Canisius Wilhelmina Ziekenhuis Nijmegen, The Netherlands   +4 more
core   +2 more sources