Results 81 to 90 of about 387,042 (307)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

A motion-decomposition approach to address gimbal lock in the 3-cylinder open chain mechanism description of a joint coordinate system at the glenohumeral joint [PDF]

, 2010
In this study, the standard-sequence properties of a joint coordinate system were implemented for the glenohumeral joint by the use of a set of instantaneous geometrical planes.
Amadi, HO, Bull, AMJ
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Incidence and mechanism of the pivot shift. An in vitro study. [PDF]

, 1999
Accepted ...
Amis, AA, Andersen, HN, Basso, O, Bull, AM, Targett, J   +4 more
core  

The Association of Dorsiflexion Flexibility on Knee Kinematics and Kinetics during a Drop Vertical Jump in Healthy Female Athletes [PDF]

, 2014
Purpose While previous studies have examined the association between ankle dorsiflexion flexibility and deleterious landing postures, it is not currently known how landing kinetics are influenced by ankle dorsiflexion flexibility.
Geiser, Christopher, Kipp, Kristof, Malloy, Philip, Meinerz, Carolyn M., Morgan, Alexander   +4 more
core   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

New Constraints on the Complex Mass Substructure in Abell 1689 from Gravitational Flexion

, 2010
In a recent publication, the flexion aperture mass statistic was found to provide a robust and effective method by which substructure in galaxy clusters might be mapped.
Adrienne Leonard, Andersson, Athreya, Bacon, Bartelmann, Bertin, Bertin, Broadhurst, Broadhurst, Carlberg, Coe, Corless, Corless, Czoske, David M. Goldberg, Diego, Duc, Dye, Frye, Gavazzi, Goldberg, Goldberg, Halkola, Hansen, Katgert, King, Koopmans, Lasky, Leonard, Leonard, Leonard, Limousin, Lin, Lindsay J. King, Mandelbaum, Meurer, Miralda Escudé, Morandi, Navarro, Oguri, Okabe, Okura, Okura, Parker, Peng, Riemer-Sørenson, Rines, Rix, Rusin, Rusin, Saha, Schneider, Schneider, Shaw, Treu, Tu, Tyson, van der Marel, Williams, Wojtak, Zekser, Łokas   +61 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Stroke-related Effects on Maximal Dynamic Hip Flexor Fatigability and Functional Implications [PDF]

, 2015
Introduction: Stroke-related changes in maximal dynamic hip flexor muscle fatigability may be more relevant functionally than isometric hip flexor fatigability.
Doyel, Ryan E., Hunter, Sandra K., Hyngstrom, Allison, Kuhnen, Henry, Onushko, Tanya, Rybar, Megan M., Schmit, Brian D.   +6 more
core   +2 more sources