Results 101 to 110 of about 53,981 (265)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Reappraising elastic thickness variation at oceanic trenches [PDF]

We reassess the variation of elastic thickness as a function of lithospheric plate age using a global database of bathymetric and free-air gravity profiles which are perpendicular to oceanic trenches.
White, N. J., Bry, M.
core   +1 more source

Development of a fully flexure-based prosthetic hand [PDF]

, 2018
Most people that require assistive devices such as prosthetic hands are located in developing countries. Two basic requirements for prosthetic hands have been identified: affordability; and, acceptance of the device.
Garcia Rodriguez, Luis Alberto
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Gravity-Insensitive Flexure Pivot Oscillators [PDF]

, 2018
Classical mechanical watch plain bearing pivots have frictional losses limiting the quality factor of the hairspring-balance wheel oscillator. Replacement by flexure pivots leads to a drastic reduction in friction and an order of magnitude increase in ...
Rubbert, Lennart, Vardi, Ilan, Kahrobaiyan, M. H., Rubbert, L. (Lennart), Thalmann, Etienne, Thalmann, E. (Etienne), Kahrobaiyan, Mohammad Hussein, Vardi, I. (Ilan), Henein, S. (Simon), Henein, Simon, Kahrobaiyan, M. (Mohammad Hussein)   +10 more
core   +2 more sources

Evaluation of the mechanical and dynamic properties of scrimber wood produced from date palm fronds

Journal of the Mechanical Behavior of Materials
This study evaluated the mechanical properties of the scrimber wood produced from date palm fronds and compared it to other wood-based materials. The raw materials for the production of the scrimber wood were date palm fronds.
Mousa Ghassan, Basha Muhammad, Moustafa Essam B.   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source