Results 81 to 90 of about 53,981 (265)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Spatial flexure mechanism analysis:Energy-based geometric stiffness modeling [PDF]

, 2020
Flexure mechanisms are used in precision applications for their ability to guide motion with high repeatability. While traditional rigid-link mechanisms move due to rolling or sliding components that induce hysteresis, flexure mechanisms move solely due ...
Nijenhuis, Marijn ; id_orcid
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Design of a Flexure-based Variable Stiffness Device for Cable-driven Joint Modules

, 2015
Robots with variable stiffness can achieve intrinsically safe motions, which are essential for human-robot interactions. This paper aims to design a variable stiffness device (VSD) for cable-driven robots.
Yang, GL, Jun Wang, Guilin Yang, Kaisheng Yang, Yang, Kaisheng, Chen, Chin-Yin, Chin-Yin Chen, Wang, Jun, Yang, Guilin   +8 more
core   +1 more source

Research on the recycled and hybrid fibre reinforced self-compacting concrete under flexure

Budownictwo i Architektura, 2020
In the present study the steel fibres coming from the end-of-life tires were applied as a reinforcement of self-compacting concrete. The influence of the recycled fibres and their mixture with glass or polypropylene fibres (hybrid mixes) on the flexural ...
Małgorzata Pająk
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Intraplate Seamounts as a Window into Deep Earth Processes [PDF]

Oceanography, 2010
Seamounts are windows into the deep Earth that are helping to elucidate various deep Earth processes. For example, thermal and mechanical properties of oceanic lithosphere can be deter-mined from the flexing of oceanic crust caused by the growth of ...
Anthony A.P. Koppers, Anthony B. Watts
doaj  

Ex vivo comparison of barbed and unbarbed sutures for the closure of caecal and pelvic flexure enterotomies in horses

Veterinaria Italiana, 2019
In this study the caecum and large colon were harvested from 24 slaughtered horses. On each sample, an 8‑cm long enterotomy was performed. Enterotomies were closed using either barbed or unbarbed glycomer‑631.
Gessica Giusto, Vittorio Caramello, Francesco Comino, Marco Gandini   +3 more
doaj   +1 more source