Results 91 to 100 of about 53,981 (265)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A buckling flexure-based force-limiting mechanism
, 2018 A force-limiting buckling flexure has been created which can be used in a wide array of applications where excessive force from an implement can cause harm or damage.
Slocum, Alexander H +8 more
core +1 more source
The Influence of External CFRP String Reinforcement on The Behavior of Flexural RC Elements
JGEET: Journal of Geoscience, Engineering, Environment and Technology, 2021 External reinforcement is an excellent method for improving the load carrying capacity and ductility behaviour of reinforced concrete members in flexure.
Junaedi Utomo +4 more
doaj
Fabrication, Experiments, and Analysis of an LBM Additive-Manufactured Flexure Parallel Mechanism
Micromachines, 2018 Additive manufacturing technology has advantages for realizing complex monolithic structures, providing huge potential for developing advanced flexure mechanisms for precision manipulation.
Huaxian Wei +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Swelling induced finite strain flexure in a rectangular block of an isotropic elastic material
, 2004 The deformation of a rectangular block into an annular wedge is studied with respect to the state of swelling interior to the block. Nonuniform swelling fields are shown to generate these flexure deformations in the absence of resultant forces and ...
Tsai, H., Kirkinis, E., Pence, T. J.
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Flexure Revisited: Strength of Singly Reinforced Beams- A Simple Approach
مجلة النهرين للعلوم الهندسية, 2015 181 singly reinforced beam tests available from the literature are investigated to obtain two flexural design methods-one simple proposal and an alternative one that takes into account the influence of rising flexural reinforcement ratio on design.
Raid I. Khalel +3 more
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