Results 111 to 120 of about 102,823 (308)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Chiral symmetry analysis and rigid rotational invariance for the lattice dynamics of single-wall carbon nanotubes

open access: yes, 2006
In this paper, we provide a detailed expression of the vibrational potential for the lattice dynamics of the single-wall carbon nanotubes (SWCNT) satisfying the requirements of the exact rigid translational as well as rotational symmetries, which is a ...
Bing-Shen Wang   +7 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Evaluation of the mechanical and dynamic properties of scrimber wood produced from date palm fronds

open access: yesJournal of the Mechanical Behavior of Materials
This study evaluated the mechanical properties of the scrimber wood produced from date palm fronds and compared it to other wood-based materials. The raw materials for the production of the scrimber wood were date palm fronds.
Mousa Ghassan   +2 more
doaj   +1 more source

Effects of vibration and shock on the performance of gas-bearing space-power Brayton cycle turbomachinery. Part 4: Suppression of rotor-bearing system vibrations through flexible bearing support damping [PDF]

open access: yes
A bearing damper, operating on the support flexure of a pivoted pad in a tilting-pad type gas-lubricated journal bearing, has been designed, built, and tested under externally-applied random vibrations. The NASA Brayton Rotating Unit (BRU), a 36,000 rpm,
Badgley, R. H.   +2 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A Probabilistic Study Of Safety Criteria For Design [PDF]

open access: yes, 1972
National Science Foundation Under Grant GK ...
Ang, A.H-S., Ellingwood, Bruce Russell
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

The Optical Velocity of the Antlia Dwarf Galaxy

open access: yes, 2000
We present the results of a VLT observing program carried out in service mode using FORS1 on ANTU in Long Slit mode to determine the optical velocities of nearby low surface brightness galaxies.
Irwin, Michael, Tolstoy, Eline
core   +1 more source

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