Results 91 to 100 of about 4,958,187 (282)

Lightweight Floating-Point Arithmetic: Case Study of Inverse Discrete Cosine Transform

open access: yesEURASIP Journal on Advances in Signal Processing, 2002
To enable floating-point (FP) signal processing applications in low-power mobile devices, we propose lightweight floating-point arithmetic. It offers a wider range of precision/power/speed/area trade-offs, but is wrapped in forms that hide the ...
Fang Fang, Chen Tsuhan, Rutenbar Rob A
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Notes on the design of a barrel shifter for the Warwick pipelined CORDIC processor [PDF]

open access: yes
This document discusses the design decisions made during the design of the barrel shifters used in the floating point adjustment circuitry of the Warwick pipelined CORDIC processor.
Chown, Paul
core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Algorithm for output of floating-point numbers in fixed-point form

open access: yesJournal of Applied Sciences and Environmental Management, 2006
Input/output of data items and information are very common operations performed on computer systems. Various data types require special ways to perform these operations on them. Floating-point numbers are no exceptions.
CB Ndeekor
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Dithering for Floating-Point Number Representation

open access: yes, 1998
Dithering is widely used for decreasing the bias in fixed-point quantization and rounding. Since floating-point digital signal processors (DSP's) and floating-point arithmetic are becoming widely used, it is timely to investigate the necessity and ...
Bernard Widrow   +2 more
core  

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