Results 81 to 90 of about 4,709,241 (239)

Study of FPGA-based Error-controllable Floating-point Operation Accelerators [PDF]

open access: yesJisuanji gongcheng
Floating-point operations are fundamental operations in the field of High-Performance Computing(HPC). In the context of big data and cloud computing,the amount of data that HPC platforms need to process is continuously growing,and the round-off error of ...
GUAN Mingxiao, LIU Jiakun, ZHANG Hongrui, HE Anping
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Lightweight Floating-Point Arithmetic: Case Study of Inverse Discrete Cosine Transform

open access: yesEURASIP Journal on Advances in Signal Processing, 2002
To enable floating-point (FP) signal processing applications in low-power mobile devices, we propose lightweight floating-point arithmetic. It offers a wider range of precision/power/speed/area trade-offs, but is wrapped in forms that hide the ...
Fang Fang, Chen Tsuhan, Rutenbar Rob A
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Notes on the design of a barrel shifter for the Warwick pipelined CORDIC processor [PDF]

open access: yes
This document discusses the design decisions made during the design of the barrel shifters used in the floating point adjustment circuitry of the Warwick pipelined CORDIC processor.
Chown, Paul
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Algorithm for output of floating-point numbers in fixed-point form

open access: yesJournal of Applied Sciences and Environmental Management, 2006
Input/output of data items and information are very common operations performed on computer systems. Various data types require special ways to perform these operations on them. Floating-point numbers are no exceptions.
CB Ndeekor
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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