Results 41 to 50 of about 6,028 (261)
Joaquín Frenguelli y las angiospermas fósiles de Patagonia
Boletín de la Sociedad Argentina de BotánicaResumen: Joaquín Frenguelli, fue un naturalista apasionado que cultivó diversas ramas de las ciencias naturales. En Paleobotánica es reconocido por sus investigaciones sobre floras paleozoicas y mesozoicas de Argentina y menos conocido por sus trabajos ...
Maria del C. Zamaloa +1 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Труды по прикладной ботанике, генетике и селекцииBackground. Biomorphological and geographic analyses conducted on long geographic gradients are relevant for identifying botanical and geographic features of segetal floras.Materials and methods.
O. G. Baranova +9 more
doaj +1 more source
Plants, People, Planet, 2020 Societal Impact Statement Plants are living repositories of pharmacologically active chemicals and help to meet society's health care needs directly, or by providing natural products for drug development.
Di Lei +5 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Palaeophytogeographical Patterns Across the Permian–Triassic Boundary
Frontiers in Earth Science, 2020 It has long been recognized that terrestrial floras underwent major and long-lasting changes during the Permian and Triassic, some of which have been attributed to the end-Permian mass extinction.
Hendrik Nowak +4 more
doaj +1 more source