Results 31 to 40 of about 278,570 (272)
Scientific ReportsIn an increasingly fragmented and isolated world, community participation remains an essential source of social connection. However, how community participation varies across countries and sociodemographic groups remains unclear.
Ying Chen +7 more
doaj +1 more source
The East Midlands in 2010: housing in the East Midlands [PDF]
, 2010 The East Midlands in 2010 is the updated evidence base that supports the regional economic strategy, A Flourishing Region.
Lawton, C
core
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
The East Midlands in 2010: sub-regional profiles [PDF]
, 2010 The East Midlands in 2010 is the updated evidence base that supports the regional economic strategy, A Flourishing Region. This document presents detailed analysis of the East Midlands' sub-regions.
Altorjai, S, Lawton, C
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Bridging across differences toward flourishing in the profession of medicine
Social Sciences and Humanities OpenBridging is a facilitative process that advances human flourishing by providing a framework for engagement across groups and between individuals with different views. It aims to increase understanding and find common ground.
Cheryl Maurana +8 more
doaj +1 more source
GoWell East Headline Indicators Comparison Report [PDF]
, 2015 This report outlines results for our GoWell East study within four separate chapters, that are focused on the Scottish Government, Commonwealth Games legacy themes: 1) Active; 2) Flourishing; 3) Sustainable; and 4) Connected. Results are presented for
Clark, Julie +4 more
core
The persistence of wishful thinking: Response to "Updated thinking on positivity ratios" [PDF]
, 2014 This is a response to Barbara Fredrickson's comment [American Psychologist 68, 814-822 (2013)] on our article arXiv:1307.7006. We analyze critically the renewed claims made by Fredrickson (2013) concerning positivity ratios and "flourishing", and ...
Brown, Nicholas J. L. +2 more
core +1 more source
Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion
FEBS Open Bio, EarlyView.Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng +2 more
wiley +1 more source
Early life experiences and adult orientation to promote good in 22 countries
Scientific ReportsPrior research suggests associations between character involving an orientation to promote good (i.e., a disposition to take actions that contribute to the good of oneself and others) and improved well-being outcomes.
Ying Chen +7 more
doaj +1 more source