Results 121 to 130 of about 2,565,967 (267)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Fluid dynamics in the vitreous chamber during infusion in ophthalmic surgery: a numerical study
FlowWe numerically investigate the fluid dynamics of the infusion of balanced salt solution into the vitreous chamber during ophthalmic surgery. A 25-gauge vitrectomy set consisting of an infusion cannula and a vitreous cutter is inserted in a realistic ...
Pier Giuseppe Ledda +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Formation of microfluidic droplets and jets in a solvent-rich oil phase
FlowWe develop original flow-based methods to interrogate and manipulate out-of-equilibrium behaviour of ternary fluids systems at the small scale. In particular, we examine droplet and jet formation of ternary fluid systems in coaxial microchannels when an ...
Victoria Joseph, Thomas Cubaud
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Turbulent boundary layer development over an air cavity
FlowThe turbulent boundary layer (TBL) development over an air cavity is experimentally studied using planar particle image velocimetry. The present flow, representative of those typically encountered in ship air lubrication, resembles the geometrical ...
Abhirath Anand +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Gravure printing with a shear-rate-dependent ink
FlowGravure printing is a type of printing method that uses metal cylinders with engraved cells that hold ink. The ink is transferred directly to the paper or other material by pressing it against the cylinder.
Pauline Rothmann-Brumm +5 more
doaj +1 more source