Results 101 to 110 of about 2,565,967 (267)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FlowMarine propellers are studied in design and off-design modes of operation like crashback, where the propeller rotates in reverse while the vehicle is in forward motion.
Thomas Bahati Kroll, Krishnan Mahesh
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Wall shear stress generated by a Bernoulli pad: experiments and numerical simulations
FlowBernoulli pads generate locally large wall shear stresses on workpieces, which can be used for cleaning, but may also damage delicate surfaces. This work presents direct measurements of the wall shear stress using constant-temperature anemometry for the ...
Anshul S. Tomar +5 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Modified Ricci flow on a principal bundle
, 2008 textLet M be a Riemannian manifold with metric g, and let P be a principal G-bundle over M having connection one-form a. One can define a modified version of the Ricci flow on P by fixing the size of the fiber.
Young, Andrea Nicole, 1979-
core
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Enhanced flow rate prediction of disturbed pipe flow using a shallow neural network
FlowTrustworthy volumetric flow measurements are essential in many applications such as power plant controls or district heating systems. Flow metering under disturbed flow conditions, such as downstream of bends, is a challenge and leads to errors of up to ...
Christoph Wilms +4 more
doaj +1 more source
Cities as Flows, Cities of Flows [PDF]
Environment and Planning B: Planning and Design, 2011 Michael Batty, James Cheshire
openaire +2 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source