Results 111 to 120 of about 6,623,538 (310)
Albeit laboratory experiments and numerical simulations have proven themselves successful in enhancing our understanding of long-living large-scale flow structures in horizontally extended Rayleigh–Bénard convection, some discrepancies with respect to ...
Philipp P. Vieweg +3 more
doaj +1 more source
Cities as Flows, Cities of Flows [PDF]
Michael Batty, James Cheshire
openaire +2 more sources
End-to-end autonomous driving systems have recently made rapid progress, thanks to simulators such as CARLA. They can drive without infraction of common driving rules on uncongested roads but are still struggling with dense traffic scenarios. We conjecture that this occurs because it lacks understanding of the dynamics of the surrounding vehicles ...
Enrico Mannocci +2 more
openaire +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Fluid mechanical aspects of blood flow in the thoracic aorta
Arterial blood flow contains structures known to be associated with arterial wall pathologies (such as atherosclerosis and aneurysms) but also with helical motion reported to be atheroprotective.
Prahl Wittberg, Lisa +2 more
core +3 more sources
Many cardiovascular diseases occur due to an abnormal functioning of the heart. A diseased heart leads to severe complications and in some cases death of an individual.
Mahesh S. Nagargoje +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A new flow law for bischofite [PDF]
Bischofite exits in the upper crust with its related minerals carnallite, sylvite and halite, and is known as the most ductile material within the halide family of minerals.
Muhammad, Nawaz +5 more
core
Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source

