Results 41 to 50 of about 3,214,265 (272)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Numerical Investigation and Performance Evaluation of Boiling Slug Flow Regime of Water Vapor in Vertical Tubes [PDF]

Journal of Applied Fluid Mechanics
The boiling phenomenon and two-phase flow regimes have provoked extensive research due to the increased heat transfer coefficient and significant industrial applications. In order to model correct heat transfer of boiling, it is important to simulate its
F. Sharifi, M. Hassani, R. Kouhikamali
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Flow boiling in copper and aluminium microchannels

International Journal of Heat and Mass Transfer, 2022
El material del sustrato y las características del lado activo pueden afectar el ciclo de ebullición de la burbuja y, en consecuencia, la tasa de transferencia de calor y la caída de presión en los evaporadores de microcanales. Este documento presenta un estudio experimental sobre los patrones de ebullición de flujo, las tasas de transferencia de calor
Ali H. Al-Zaidi, Mohamed M. Mahmoud, Tassos G. Karayiannis   +2 more
openaire   +3 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Modelling pressure fluctuations during flow boiling in microchannels with inlet compressibility and resistance [PDF]

, 2009
Confined bubble growth during flow boiling at low pressures in microchannels generates pressure fluctuations that may cause transient flow reversals that disturb the flow distribution in heat sinks formed of parallel channels joined by plena.
Gedupudi, S, Karayiannis, TG, Kenning, DBR   +2 more
core   +5 more sources

Experimental study of flow boiling heat transfer and pressure drop in stepped oblique-finned microchannel heat sink

Case Studies in Thermal Engineering, 2022
Oblique-finned microchannels have been reported to enhance heat transfer performance and suppress the flow boiling instability, but they can also cause an increase in pressure drop.
Juncheng Qiu, Qi Zhao, Mingxiang Lu, Jianhong Zhou, Dinghua Hu, Hanshi Qin, Xuemei Chen   +6 more
doaj   +1 more source

Flow Boiling in Minichannels [PDF]

, 2006
The use ofmini-channel heat exchangers (hydraulic diameter about 1 mm) in compact heat exchangers improves heat transfer coefficients, and thermal efficiency while requiring a lower fluid mass. They are widely used in condensers for automobile air-conditioning and are now being used in evaporators, as well as in other applications such as domestic air ...
André Bontemps, Bruno Agostini, Nadia Caney   +2 more
openaire   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Visualization Study on Flow Pattern Evolution and Heat Transfer Characteristics of a Two-Phase Loop Thermosyphon Under High Heat Flux with Various Filling Ratios

Energies
To investigate the flow pattern evolution and phase-change characteristics of a two-phase loop thermosyphon under high heat flux conditions with different filling ratios, a visual experimental study was conducted.
Chenxian Yin, Kuiming Wang, Jiapeng Zhou, Dawei Tang   +3 more
doaj   +1 more source