Results 101 to 110 of about 5,222,192 (298)

Numerical study on the cerebral blood flow regulation in the circle of Willis with the vascular absence and internal carotid artery stenosis

Frontiers in Bioengineering and Biotechnology
ObjectivesThis study explores how vascular stenosis and absence affect the regulation of cerebral blood flow in the Circle of Willis (CoW) and the hemodynamic changes downstream of the stenosis.Materials and MethodsForty idealized CoW models were ...
Hong Lv, Hong Lv, Kailei Fu, Wei Liu, Zhiyi He, Zhiqing Li   +5 more
doaj   +1 more source

Particle transport and deposition correlation with near-wall flow characteristic under inspiratory airflow in lung airways. [PDF]

Comput Biol Med, 2020
Farghadan A, Poorbahrami K, Jalal S, Oakes JM, Coletti F, Arzani A.   +5 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Mass Flow Rate Characteristic of the Flapper-nozzle Pneumatic Valve [PDF]

, 2015
Flapper-nozzle type valve is commonly used for precision, flow control in pneumatic systems. For the purpose of analysis and design the paper is concerned with nonlinear mass flow rate of the valve taking into account different flow regimes. Flow rate is
Dubonjic, Ljubisa, Pršić, Dragan, Nedić, Novak   +2 more
core  

Vortex valve

EPJ Web of Conferences, 2018
The paper deals with a flow field inside the so-called vortex valve, used as an outlet device on retention reservoirs for retention of rainstorms and later slow outflow into sewerage etc. The system is very simple, without moving parts.
Adámek Karel, Kolář Jan, Peukert Pavel   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The control characteristic shaping of fluid mass flow adjustment elements [PDF]

, 2007
W artykule przedstawiono koncepcję elementów nastawczych: zasuwy, przepustnicy oraz zaworu grzybkowego, które charakteryzują się dobrze założoną zależnością między strumieniem płynu a stopniem ich otwarcia.
Wnęk, M., Puszer, A., Tomeczek, J.
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source