Results 121 to 130 of about 1,828,109 (317)

Numerical Study on Flow Characteristics of the Slurry-Feeding System in a Hydrojet Shield

Fluids
The hydrojet-shield machine, a rapidly advancing shield machine type, uses slurry for excavation and muck removal via a pipeline system. The pipeline includes a flushed feeding system that injects slurry into areas at risk of obstruction.
Hao Jia, Hao Feng, Yapeng Wang, Jiuchun Sun, Xiaopeng Sun, Yunlong Sang, Haitao Wang   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Flow induced viscoelasticity in fractures

, 2016
The behaviour of viscoelastic surfactant solutions under pressure driven flow in fractures is studied with particle image velocimetry. We demonstrate that flow is selectively retarded in larger conduits and we zoom in to smaller scales in order to ...
van der Plas, B.A., Golombok, M.
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Effects of Radial Clearance Between Rotor and Casing on Flow Characteristics in a Centrifugal Pump

Machines
The electrification of the automotive industry and the lightweighting of aerospace equipment demand high-efficiency centrifugal pumps for compact spaces.
Junjie Bian, Yandong Gu, Qiyuan Zhu, Weigang Lu   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Transport characteristics and blockage mechanism of fractured rock mass during water inrush process in roadway

Meitan kexue jishu
Mine water inrush and collapse accidents are among the most destructive geological disasters, where the movement and deposition behavior of solid–fluid two-phase flows directly determine the scale of disaster evolution and the difficulty of mitigation ...
Guichen LI, Xiaofang WO, Sen YANG, Yuantian SUN, Jinghua LI, Haoran HAO, Zeyu SHAO   +6 more
doaj   +1 more source

Characteristics of Debris Flow Cylindrical Flow Traces

, 2023
This is the data set and video of the debris-flow ...
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Stratified Flow Characteristics and Internal Tide in Gokasho Bay

, 1996
Field observation to clarify flow characteristics of Gokasho Bay was carried out in 1993. In this paper, based on the results, stratified flow characteristics and internal tide of the bay was presented.
2019, タケウチ, トモユキ, 武内, 智行, 80116946, Takeuchi, Tomoyuki   +4 more
core