Results 131 to 140 of about 1,828,109 (317)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
MetalsAutomotive roof racks are important lightweight accessories for vehicles, and their extrusion performance is affected by the coupled effects of material hot deformation behavior, die flow resistance and billet surface layer transport. In this study, Al-0.
Anna Cheng +6 more
doaj +1 more source
Turbulence characteristics of particle-laden pipe flow
, 2007 Turbulence characteristics of vertical air-solid pipe flow are investigated in this paper. Direct numerical simulations of the gas phase have been performed, while the solid particles have been simulated by a Lagrangian approach, including particle ...
Vreman, A. W., Vreman, AW Bert
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2012 Flow boiling heat transfer characteristics of CO2 with and without oil were investigated experimentally in horizontal smooth and enhanced tubes with an inner diameter of 11.2 mm.
Hrnjak, Predrag S., Kim, Seongho
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Flow boiling of R134a in vertical mini-diameter tubes
, 2011 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 21/03/2011.The current study is a part of a long term experimental project devoted to investigate flow boiling heat transfer, pressure drop and flow ...
Mahmoud M, Mohamed M
core
Processing and fluid flow characteristics of hot isostatically pressed porous alumina for aerostatic bearing applications [PDF]
, 1996 Despite their well known superior load and stiffness characteristics, the wide-spread use of porous aerostatic bearings in preference to other bearing types has been hampered by difficulties in controlling the permeability of the porous material during
Kwan, Y. B. P
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source