Results 171 to 180 of about 1,828,109 (317)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Nonlinear flow characteristics of cement grout in fractures with varying geometries. [PDF]

Sci Rep
Li X, Zhao W, Zhang J, Ma Y, Chen L.
europepmc   +1 more source

Flow Resistance of Metallic Screens in Liquid, Gaseous and Cryogenic Flow

, 2013
Fine metallic screens are important sub-systems in propellant tank systems of spacecrafts due to their application as filter devices. The flow resistance has to be known for a proper design of tank and feed line systems.
Gerstmann, Jens, Fischer, A., Fischer, Alexander   +2 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Investigation of Flow Characteristics in a Stirred-Tank Bioreactor with Flexible Blades via Integrated PIV and Image Recognition. [PDF]

Bioengineering (Basel)
Xu W, Cai C, Li Z, Lu H, Yang C, Liu B.
europepmc   +1 more source

Measurement of Mist to Annular Flow Development in the Discharge of a Compressor

, 2012
Compressors produce a flow of oil droplets propelled by refrigerant flow while fully developed flow maps predict predominantly annular flow. This discrepancy is rooted in the lack of understanding of flow development.
Wujek, Scott S., Hrnjak, Predrag S.
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Shaping the flow characteristics of a proportional directional valve. [PDF]

Sci Rep
Kosek M, Sliwinski P.
europepmc   +1 more source

Saturated flow boiling in small- to micro- diameter metallic tubes: Experimental results and modeling

, 2008
Some results of a long-term study of flow boiling patterns, heat transfer rates and pressure drop of R134a at pressures of 6-14 bar in five vertical stainless steel tubes of internal diameter 4.26, 2.88, 2.01, 1.1 and 0.52 mm are presented in this paper.
Karayiannis, TG, Shiferaw, D, Kenning, DBR   +2 more
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source