Results 61 to 70 of about 18,578,793 (360)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Research on swimming hydrodynamics based on a three‐dimensional high‐precision fish model

open access: yesRiver
Fish swimming hydrodynamics serves as a critical foundation for aquatic ecological conservation, with recent research extending from 2D to 3D perspectives.
Lin Sun   +4 more
doaj   +1 more source

Flow characteristics of caved ore and rock in the multiple draw-point condition

open access: yes工程科学学报, 2015
Based on the particle flow theory and PFC3D code,a draw model was constructed to research the flow characteristics of caved ore and rock in the multiple draw-point condition and visualize the form-changing process of the isolated extraction zone(IEZ) and
SUN Hao   +3 more
doaj   +1 more source

Prediction of performance of centrifugal pumps during starts under pressure [PDF]

open access: yes, 1969
Method which calculates start-up characteristics of centrifugal pumps reveals a capacity to predict pressure drop characteristics of pumps with vaned diffusers. Calculations are based on pump geometry, design-point flow, speed, and pressure rise, and the
Rostafinski, W.
core   +1 more source

Analysis of CavoPulmonary and Cardiac Flow Characteristics in Fontan Patients: Comparison with Healthy Volunteers

open access: yesJournal of Magnetic Resonance Imaging, 2019
Characterizing the flow of the Fontan circuit, and correlating flow characteristics with the development of complications, is an important clinical challenge.
David R. Rutkowski   +5 more
semanticscholar   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait   +23 more
wiley   +1 more source

Influencing factors on the flow characteristics of an isolated extraction zone in caving mining

open access: yes工程科学学报, 2015
Based on the particle flow theory and PFC3D code, a draw model with the meso-mechanical properties of ore granular media was constructed to study influencing factors on the flow characteristics of an isolated extraction zone in caving mining.
SUN Hao   +4 more
doaj   +1 more source

Numerical Investigation on Flow Separation Control of Low Reynolds Number Sinusoidal Aerofoils [PDF]

open access: yes, 2016
The paper presents a computational analysis of the characteristics of a NACA 634- 021 aerofoil incorporated with sinusoidal leading-edge protuberances at Re = 14,000. The protuberances are characterized by an amplitude and wavelength of 12% and 50% of
Cai C.   +4 more
core   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

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