Results 131 to 140 of about 521,952 (287)

Modern flow chemistry - prospect and advantage. [PDF]

Beilstein J Org Chem, 2023
Heretsch P.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

WANTED: Flow Chemistry Reaction Data

CHIMIA
Flow reaction data could have an outsized impact in the datasets which train the reaction prediction, chemical synthesis planning, and experiment design tools of tomorrow. This paper discusses why we should be increasing the availability of flow reaction
Benjamin J. Deadman
doaj   +1 more source

Synthesis of Dolutegravir Exploiting Continuous Flow Chemistry. [PDF]

J Org Chem, 2023
Nqeketo S, Watts P.
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

A consistent molecular hydrogen isotope chemistry scheme based on an independent bond approximation

, 2009
The isotopic composition of molecular hydrogen (H₂) produced by photochemical oxidation of methane (CH₄) and Volatile Organic Compounds (VOCs) is a key quantity in the global isotope budget of (H<sub>2 ...
Sub Atmospheric physics and chemistry, M. C. Krol, G. Pieterse, T. Röckmann, Krol, M.C., Pieterse, G., Afd Marine and Atmospheric Research, Marine and Atmospheric Research, Röckmann, T.   +8 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

General aspects of immobilized biocatalysts and their applications in flow

, 2018
Biocatalysis provides a unique opportunity to create complex and chiral molecules with unprecedented selectivity.[1-8] Enzymes are the preferred catalysts.[9-13] "White biotechnology" exploits biocatalysis on an industrial level, and the number of ...
Znidarsic-Plazl, P., Bajic, M., Brøndsted Nielsen, Mogens, Krause, N., Ramsden, C.A., Kingston, M., Hessel, V., Rademann, J., Reissig, H.-U.   +8 more
core   +1 more source

Key Fabrications of Chitosan Nanoparticles for Effective Drug Delivery Using Flow Chemistry Reactors. [PDF]

Int J Nanomedicine, 2023
Huanbutta K, Sriamornsak P, Suwanpitak K, Klinchuen N, Deebugkum T, Teppitak V, Sangnim T.   +6 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source