Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
Continuous Flow Decarboxylative Monofluoroalkylation Enabled by Photoredox Catalysis
JACS AuFrancesco Pasca +8 more
doaj +1 more source
Flow chemistry-enabled asymmetric synthesis of cyproterone acetate in a chemo-biocatalytic approach. [PDF]
Nat CommunZhang Y +6 more
europepmc +1 more source
Efficient degassing and ppm-level oxygen monitoring flow chemistry system.
React Chem Eng, 2023 Baronas P, Elholm JL, Moth-Poulsen K.
europepmc +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Sustainability and Techno-Economic Assessment of Batch and Flow Chemistry in Seven Industrial Pharmaceutical Processes. [PDF]
ACS Sustain Chem EngInce MC, Benyahia B, Vilé G.
europepmc +1 more source
Flow Chemistry-Enabled Divergent and Enantioselective Total Syntheses of Massarinolin A, Purpurolides B, D, E, 2,3-Deoxypurpurolide C, and Structural Revision of Massarinolin A. [PDF]
Angew Chem Int Ed Engl, 2021 Wang YC, Cui C, Dai M.
europepmc +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source