Results 161 to 170 of about 1,479,587 (285)

Accelerated synthesis of immunomodulatory imide drugs and their derivatives via continuous flow chemistry. [PDF]

Commun Chem
Hou T, Huang J, Li Y, Zhu Y, You H, Chen FE.   +5 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Flow Chemistry Enabled Asymmetric Total Synthesis of (+)-Biotin through Pseudocatalytic Strategy. [PDF]

JACS Au
Zheng X, Gao L, Zhang Y, Wu J, Cheng D, Wan L, Chen F.   +6 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Modular Synthesis of Substituted Lactams via a Deoxygenative Photochemical Alkylation–Cyclization Cascade of Secondary Amides in Flow

JACS Au
Damiano Diprima, Thomas Terp Paulsen, Antonio Pulcinella, Stefano Bonciolini, Alexis L. Gabbey, Robin Stuhr, Thomas Bjørnskov Poulsen, Timothy Noël   +7 more
doaj   +1 more source

Advances in Flow Chemistry for Organolithium-Based Synthesis: A Process Perspective. [PDF]

Molecules
Zhou F, Zhou Y, Duanmu C, Li Y, Li J, Xu H, Wang P, Zhu K.   +7 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A Novel Flow Chemistry Approach to Covalent Functionalization of 3D Graphene Aerogels. [PDF]

ACS Omega
Carbonaro AB, Greco V, Pifferi V, Falciola L, Ciliberto E, Gulino A, Giuffrida A.   +6 more
europepmc   +1 more source

Accelerating the end-to-end production of cyclic phosphate monomers with modular flow chemistry. [PDF]

Chem Sci, 2022
Morodo R, Riva R, van den Akker NMS, Molin DGM, Jérôme C, Monbaliu JM.   +5 more
europepmc   +1 more source

Continuous flow chemistry [PDF]

, 2021
openaire   +1 more source