Results 161 to 170 of about 6,410,488 (278)

Accelerated synthesis of immunomodulatory imide drugs and their derivatives via continuous flow chemistry. [PDF]

Commun Chem
Hou T, Huang J, Li Y, Zhu Y, You H, Chen FE.   +5 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Continuous Flow Decarboxylative Monofluoroalkylation Enabled by Photoredox Catalysis

JACS Au
Francesco Pasca, Yuri Gelato, Michael Andresini, Defne Serbetci, Philipp Natho, Giuseppe Romanazzi, Leonardo Degennaro, Marco Colella, Renzo Luisi   +8 more
doaj   +1 more source

Flow Chemistry Enabled Asymmetric Total Synthesis of (+)-Biotin through Pseudocatalytic Strategy. [PDF]

JACS Au
Zheng X, Gao L, Zhang Y, Wu J, Cheng D, Wan L, Chen F.   +6 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

A Novel Flow Chemistry Approach to Covalent Functionalization of 3D Graphene Aerogels. [PDF]

ACS Omega
Carbonaro AB, Greco V, Pifferi V, Falciola L, Ciliberto E, Gulino A, Giuffrida A.   +6 more
europepmc   +1 more source

Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry. [PDF]

Chem Rev, 2022
Buglioni L, Raymenants F, Slattery A, Zondag SDA, Noël T.   +4 more
europepmc   +1 more source

Continuous flow chemistry [PDF]

, 2021
openaire   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Deep Reinforcement Learning-Based Self-Optimization of Flow Chemistry. [PDF]

ACS Eng Au
Yewale A, Yang Y, Nazemifard N, Papageorgiou CD, Rielly CD, Benyahia B.   +5 more
europepmc   +1 more source