Results 171 to 180 of about 521,952 (287)

Continuous Flow Decarboxylative Monofluoroalkylation Enabled by Photoredox Catalysis

JACS Au
Francesco Pasca, Yuri Gelato, Michael Andresini, Defne Serbetci, Philipp Natho, Giuseppe Romanazzi, Leonardo Degennaro, Marco Colella, Renzo Luisi   +8 more
doaj   +1 more source

Flow Chemistry Enabled Asymmetric Total Synthesis of (+)-Biotin through Pseudocatalytic Strategy. [PDF]

JACS Au
Zheng X, Gao L, Zhang Y, Wu J, Cheng D, Wan L, Chen F.   +6 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

A Novel Flow Chemistry Approach to Covalent Functionalization of 3D Graphene Aerogels. [PDF]

ACS Omega
Carbonaro AB, Greco V, Pifferi V, Falciola L, Ciliberto E, Gulino A, Giuffrida A.   +6 more
europepmc   +1 more source

Scalable synthesis of favipiravir via conventional and continuous flow chemistry. [PDF]

RSC Adv, 2021
Tiyasakulchai T, Charoensetakul N, Khamkhenshorngphanuch T, Thongpanchang C, Srikun O, Yuthavong Y, Srimongkolpithak N.   +6 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Deep Reinforcement Learning-Based Self-Optimization of Flow Chemistry. [PDF]

ACS Eng Au
Yewale A, Yang Y, Nazemifard N, Papageorgiou CD, Rielly CD, Benyahia B.   +5 more
europepmc   +1 more source

Accelerating the end-to-end production of cyclic phosphate monomers with modular flow chemistry. [PDF]

Chem Sci, 2022
Morodo R, Riva R, van den Akker NMS, Molin DGM, Jérôme C, Monbaliu JM.   +5 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Role of Flow Chemistry on the Synthesis of Pyrazoles, Pyrazolines and Pyrazole-Fused Scaffolds. [PDF]

Molecules
Correia CM, Silva AMS, Silva VLM.
europepmc   +1 more source