Results 21 to 30 of about 2,666 (99)

A sustainable strategy for the straightforward preparation of 2H-azirines and highly functionalized NH-aziridines from vinyl azides using a single solvent flow-batch approach

Beilstein Journal of Organic Chemistry, 2021
The reported flow-batch approach enables the easy preparation of 2H-azirines and their stereoselective transformation into highly functionalized NH-aziridines, starting from vinyl azides and organolithium compounds.
Michael Andresini, Leonardo Degannaro, Renzo Luisi   +2 more
doaj   +1 more source

C(sp3)–H sulfinylation of light hydrocarbons with sulfur dioxide via hydrogen atom transfer photocatalysis in flow

Nature Communications
Sulfur-containing scaffolds originating from small alkyl fragments play a crucial role in various pharmaceuticals, agrochemicals, and materials. Nonetheless, their synthesis using conventional methods presents significant challenges.
Dmitrii Nagornîi, Fabian Raymenants, Nikolaos Kaplaneris, Timothy Noël   +3 more
doaj   +1 more source

Stereo- and Enantioselective Addition of Organolithiums to 2-Oxazolinylazetidines as a Synthetic Route to 2-Acylazetidines

Frontiers in Chemistry, 2019
A new synthetic route to N-alkyl-2-acylazetidines was developed through a highly stereoselective addition of organolithiums to N-alkyl-2-oxazolinylazetidines followed by acidic hydrolysis of the resulting oxazolidine intermediates. This study revealed an
Pantaleo Musci, Marco Colella, Flavio Fanelli, Flavio Fanelli, Angela Altomare, Luisa Pisano, Claudia Carlucci, Renzo Luisi, Leonardo Degennaro   +8 more
doaj   +1 more source

Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow

Beilstein Journal of Organic Chemistry, 2020
The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison ...
Alexander V. Nyuchev, Ting Wan, Borja Cendón, Carlo Sambiagio, Job J. C. Struijs, Michelle Ho, Moisés Gulías, Ying Wang, Timothy Noël   +8 more
doaj   +1 more source

Deoxygenative photochemical alkylation of secondary amides enables a streamlined synthesis of substituted amines

Nature Communications
Secondary amines are vital functional groups in pharmaceuticals, agrochemicals, and natural products, necessitating efficient synthetic methods. Traditional approaches, including N-monoalkylation and reductive amination, suffer from limitations such as ...
Antonio Pulcinella, Stefano Bonciolini, Robin Stuhr, Damiano Diprima, Minh Thao Tran, Magnus Johansson, Axel Jacobi von Wangelin, Timothy Noël   +7 more
doaj   +1 more source

Window of opportunity – potential of increase in profitability using modular compact plants and micro-reactor based flow processing

Green Processing and Synthesis, 2012
Recently, much focus has been given to a new type of chemical production plant, with the aim of a much faster time-to-market (“50% idea”) and better cash-flow revenue. The main enabling technology is to have the plants pre-manufactured and assembled by a
Gürsel Iris Vural, Hessel Volker, Wang Qi, Noël Timothy, Lang Jürgen   +4 more
doaj   +1 more source

Continuous Flow Synthesis of Heterocycles: A Recent Update on the Flow Synthesis of Indoles

Molecules, 2020
Indole derivatives are among the most useful and interesting heterocycles employed in drug discovery and medicinal chemistry. In addition, flow chemistry and flow technology are changing the synthetic paradigm in the field of modern synthesis.
Marco Colella, Leonardo Degennaro, Renzo Luisi   +2 more
doaj   +1 more source

Four-layer folding framework: design, GAP synthesis, and aggregation-induced emission

Frontiers in Chemistry, 2023
The design and synthesis of a type of [1 + 4 + 2] four-layer framework have been conducted by taking advantage of Suzuki–Miyaura cross-coupling and group-assisted purification (GAP) chemistry.
Sai Zhang, Sai Zhang, Daixiang Chen, Jia-Yin Wang, Shenghu Yan, Guigen Li   +5 more
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Rapid and scalable photocatalytic C(sp2)–C(sp3) Suzuki−Miyaura cross-coupling of aryl bromides with alkyl boranes

Nature Communications
In recent years, there has been a growing demand for drug design approaches that incorporate a higher number of sp3-hybridized carbons, necessitating the development of innovative cross-coupling strategies to reliably introduce aliphatic fragments. Here,
Ting Wan, Luca Capaldo, Jonas Djossou, Angela Staffa, Felix J. de Zwart, Bas de Bruin, Timothy Noël   +6 more
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Solvent Resistant O2 Sensor Integrated in Pressured Flow Reactors

Proceedings, 2019
In this contribution we present an optical oxygen sensor that can easily be integrated into continuous flow reactors. The sensors are pressure resistant to up to 8 bars and are able to continuously measure oxygen for several hours in organic solvents ...
Philipp Sulzer, René Lebl, Torsten Mayr
doaj   +1 more source