Results 51 to 60 of about 1,472,154 (285)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Rapid and scalable photocatalytic C(sp2)–C(sp3) Suzuki−Miyaura cross-coupling of aryl bromides with alkyl boranes

Nature Communications
In recent years, there has been a growing demand for drug design approaches that incorporate a higher number of sp3-hybridized carbons, necessitating the development of innovative cross-coupling strategies to reliably introduce aliphatic fragments. Here,
Ting Wan, Luca Capaldo, Jonas Djossou, Angela Staffa, Felix J. de Zwart, Bas de Bruin, Timothy Noël   +6 more
doaj   +1 more source

Continuous Flow Synthesis of Heterocycles: A Recent Update on the Flow Synthesis of Indoles

Molecules, 2020
Indole derivatives are among the most useful and interesting heterocycles employed in drug discovery and medicinal chemistry. In addition, flow chemistry and flow technology are changing the synthetic paradigm in the field of modern synthesis.
Marco Colella, Leonardo Degennaro, Renzo Luisi   +2 more
doaj   +1 more source

Immersed superhydrophobic surfaces: Gas exchange, slip and drag reduction properties [PDF]

, 2009
Superhydrophobic surfaces combine high aspect ratio micro- or nano-topography and hydrophobic surface chemistry to create super water-repellent surfaces. Most studies consider their effect on droplets, which ball-up and roll-off.
Bachhuber, Barthlott, Bocquet, Boussinesq, Bush, Cassie, Crisp, Davis, De Rybczynski, Ege, Evans, Extrand, Flynn, Gao, Glen McHale, Hadamard, Hinton, Johnson, Kulinich, Kusumaatmaja, Landau, Lauga, Lee, Lee, Li, Marmur, McHale, McHale, Michael I. Newton, Neil J. Shirtcliffe, Neto, Onda, Ou, Priest, Quéré, Reyssat, Richardson, Roach, Roach, Rushton, Saito, Schuyten, Schuyten, Shirtcliffe, Shirtcliffe, Steinberger, Stokes, Thorpe, Thorpe, Tourkine, Turner, Tuteja, Vinogradova, Vogler, Voronov, Zhang, Zhang, Zheng   +57 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Metallic nanoparticles made in flow and their catalytic applications in organic synthesis

Nanotechnology Reviews, 2014
This paper reviews recent developments on the synthesis of noble metal nanoparticles in micro and millifluidic devices and their catalytic application in organic flow synthesis.
Shahbazali Elnaz, Hessel Volker, Noël Timothy, Wang Qi   +3 more
doaj   +1 more source

Solvent Resistant O2 Sensor Integrated in Pressured Flow Reactors

Proceedings, 2019
In this contribution we present an optical oxygen sensor that can easily be integrated into continuous flow reactors. The sensors are pressure resistant to up to 8 bars and are able to continuously measure oxygen for several hours in organic solvents ...
Philipp Sulzer, René Lebl, Torsten Mayr
doaj   +1 more source

Capillary electrophoresis-UV analysis using silica-layer coated capillary for separation of seven phenolic acids and caffeine and its application to tea analysis

SN Applied Sciences, 2021
This work presents an innovative silica-layer coated capillary with comparison study of the silica-layer coated capillary and the fused-silica capillary for the separation of seven phenolic acids viz.
Pattamaporn Hemwech, Apinya Obma, Sasinun Detsangiamsak, Supa Wirasate, Pimchai Chaiyen, Prapin Wilairat, Rattikan Chantiwas   +6 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source