Results 81 to 90 of about 1,472,154 (285)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
, 2020 Flow chemistry is an expanding area of chemistry. Today, it is also starting to contribute to the development of new and exciting sustainable and green methods to new chemicals and materials. In this special issue, we have collected papers from leading scientists in the field presenting numerous examples illustrating the power of flow chemistry.
Paradisi, Francesca, Woodley, John M.
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Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Simulation of hydrogen auto-ignition in a turbulent co-flow of heated air with LES and CMC approach [PDF]
, 2011 Large-Eddy Simulations (LES) with the first order Conditional Moment Closure (CMC) approach of a nitrogen-diluted hydrogen jet, igniting in a turbulent co-flowing hot air stream, are discussed. A detailed mechanism (nine species, 19 reactions) is used to
Lacor, Chris +4 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
TASK Quarterly, 2018 Numerical modelling of hydrogen production by means of methanol decomposition in a thermocatalytic reactor using corrugated foil made of the Ni3Al intermetallic phase is shown in the paper.
PAWEŁ ZIÓŁKOWSKI +5 more
doaj +1 more source
A study of numerical methods for hyperbolic conservation laws with stiff source terms [PDF]
The proper modeling of nonequilibrium gas dynamics is required in certain regimes of hypersonic flow. For inviscid flow this gives a system of conservation laws coupled with source terms representing the chemistry.
Leveque, R. J., Yee, H. C.
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Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Peptide Bond Formations through Flow Chemistry [PDF]
Chemical Biology & Drug Design, 2017 Flow chemistry could play a key role in the development of fast‐automated synthesis of peptides and proteins through the quick activation of intermediates for coupling at low concentrations of reagents. The selected examples highlight the role of flow chemistry for the advancements of peptides bond formations.
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Radiative interactions in chemically reacting supersonic internal flows [PDF]
The two-dimensional, elliptic Navier-Stokes equations are used to investigate supersonic flows with finite-rate chemistry and radiation for hydrogen-air systems.
Chandrasekhar, R., Tiwari, S. N.
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