Results 171 to 180 of about 2,574,025 (316)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Melt flow control on lithological and geochemical heterogeneity of the oceanic upper mantle. [PDF]

Natl Sci Rev
Rui HC, Doucet LS, Lissenberg CJ, Lian DY, Li J, Cai PJ, Lai SM, Zhu JX, He HP, Yang JS.   +9 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Sympathetic Stress and Sleep Loss in Diabetic Retinopathy: Links to Retinal Blood-Flow Control. [PDF]

Biomedicines
Tan M, Liu S, Fang M, Yuan M, Niu D, Wang Y, Zhou H, Zeng J, Dai Y, Song S.   +9 more
europepmc   +1 more source

Simulating the dynamics of primary cilium in pulsatile flow by the immersed boundary-lattice Boltzmann method

5th Symposium on Flow-Structure-Sound Interactions and Control (FSSIC), 27 to 30 August 2019, Minoa Palace Resort in Chania, Crete Island, Greece202405 bcchAccepted ManuscriptSelf-fundedPublishedGreen ...
Liu, Y, Xiao, L, Cui, J, Chen, S
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A dataset of wind tunnel measurements for a laboratory demonstrator of a small ducted wind turbine equipped with passive flow control devices. [PDF]

Data Brief
Coșoiu CI, Chiulan EA, Popescu O, Georgescu AM.   +3 more
europepmc   +1 more source

Electrical Drive DC Link Power Flow Control with Adaptive Approach

An objective to control power flow in intermediate DC link of typical induction drive converter has been introduced and respective drive setup intended for such task.
Paugurs, Artūrs, Šenfelds, Armands
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Sponge-Based Flow Control in Laminate Capillary-Driven Electrochemical Microfluidic Devices for Viscous Sample Analysis. [PDF]

Anal Chem
Araújo DAG, Baldo TA, Paixão TRLC, Henry CS.   +3 more
europepmc   +1 more source