Results 181 to 190 of about 6,124,378 (340)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Evaluation of flow control using PID versus fuzzy logic in an electropneumatic circuit for pulmonary ventilation applications. [PDF]

PLoS One
González L, Griffith I, Lescher A, Molino J, Rojas A, Quijano D.   +5 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

A case of severe carotid blowout syndrome successfully treated with endovascular parent artery occlusion: Additional N-butyl cyanoacrylate embolization under flow control after incomplete coil embolization. [PDF]

Surg Neurol Int
Shida K, Matsuyama H, Shibuya K, Morita K, Murai S, Nakayama Y, Nakamura K, Fukumoto J, Sakata Y, Takashima J, Saito A.   +10 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A case of multi-plug flow control technique treating high flow cirsoid renal arteriovenous malformations. [PDF]

Med Pharm Rep
Çelebioğlu EC, Gursoy AC, Dabus M, Bilgiç S.   +3 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Experimental and numerical investigation of endwall flow control through air injection in a contra rotating fan. [PDF]

Sci Rep
Sadoddin M, Khaleghi H.
europepmc   +1 more source

Nanomechanical Sensing for Mass Flow Control in Nanowire-Based Open Nanofluidic Systems. [PDF]

ACS Nano, 2023
Escobar JE, Molina J, Gil-Santos E, Ruz JJ, Malvar Ó, Kosaka PM, Tamayo J, San Paulo Á, Calleja M.   +8 more
europepmc   +1 more source

Advanced Thermal Management of High Temperature Fuel Cells via Active Flow Control

, 2007
Patrick Alain Louka
openalex   +1 more source