Results 241 to 250 of about 1,073,278 (354)

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source

Imaging flow cytometry as a novel approach for the diagnosis of heparin-induced thrombocytopenia. [PDF]

Br J Haematol
Carré J, Demont Y, Mouton C, Vayne C, Guéry EA, Voyer A, Garçon L, Le Guyader M, Demagny J.   +8 more
europepmc   +1 more source

Comparative analysis of lymphocyte phenotypes between carriers of human immunodeficiency virus(HIV) and adult patients with primary immunodeficiency using two-color immunofluorescence flow cytometry.

, 1988
Tatsuharu Ohno, T Kanoh, Takayo Suzuki, Tohru Masuda, Kagemasa Kuribayashi, Shinichi Araya, HISAJI ARAI, Haruto Uchino   +7 more
openalex   +2 more sources

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

Advanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle, Dhruv Menon, João Conniot, Jon Ostolaza‐Paraiso, Sergio Mercado, Jhenifer Oliveira, Xu Chen, Bárbara B. Mendes, João Conde, David Fairen‐Jimenez   +9 more
wiley   +1 more source

Stimulated Brillouin scattering flow cytometry. [PDF]

Biomed Opt Express
Rosvold JR, Zanini G, Handler C, Frank E, Li J, Vitolo MI, Martin SS, Scarcelli G.   +7 more
europepmc   +1 more source

Flow cytometry method for the analysis of membrane-associated human chorionic gonadotropin, its subunits, and fragments on human cancer cells [PDF]

, 1992
Hernan F. Acevedo, Alexander Krichevsky, Elizabeth A. Campbell-Acevedo, Joyce C. Galyon, Mary Jo Buffo, Robert J. Hartsock   +5 more
openalex   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Protocol for assessing murine cell doublet engagement and subsequent effects using flow cytometry and imaging flow cytometry. [PDF]

STAR Protoc
Shapir Itai Y, Porat Z, Dahan R.
europepmc   +1 more source

State‐of‐the‐Art, Insights, and Perspectives for MOFs‐Nanocomposites and MOF‐Derived (Nano)Materials

Advanced Materials, EarlyView.
Different approaches to MOF‐NP composite formation, such as ship‐in‐a‐bottle, bottle‐around‐the‐ship and in situ one‐step synthesis, are used. Owing to synergistic effects, the advantageous features of the components of the composites are beneficially combined, and their individual drawbacks are mitigated.
Stefanos Mourdikoudis, Subhajit Dutta, Saqib Kamal, Sergio Gómez‐Graña, Isabel Pastoriza‐Santos, Stefan Wuttke, Lakshminarayana Polavarapu   +6 more
wiley   +1 more source

Cardiac Organoid Model Inspired Micro‐Robot Smart Patch to Treat Myocardial Infarction

Advanced Materials, EarlyView.
The heart organoid model exhibits the acidic microenvironment characteristic of myocardial infarction, which emerges as a pivotal force propelling the movement of micro‐robots. These micro‐robots, administered through microneedles, can penetrate deep into the tissue, effectively delivering therapeutic payloads to facilitate heart repair.
Fangfang Wang, Zilu Xu, Feiyang Zheng, Dongcheng Yang, Kaige Xu, Ming Ke, Xiao Zhou, Xiaohan Zhang, Ju Tan, Yong Liu, Yansha Hao, Malcolm Xing, Chuhong Zhu   +12 more
wiley   +1 more source