Results 81 to 90 of about 5,722 (296)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Case Report: “Stent-within-a-Stent” technique after telescopic flow diverter reconstruction for basilar artery aneurysm with proximal stenosis

Frontiers in Surgery
BackgroundComplex basilar artery aneurysms are challenging to treat due to their deep anatomical location and proximity to critical perforating arteries, as well as their frequent fusiform morphology and association with long-segment stenosis or ...
Iroda Mammadinova, Chingiz Nurimanov, Nurtay Nurakay, Karashash Menlibayeva, Serik Akshulakov, Yerbol Makhambetov   +5 more
doaj   +1 more source

Accuracy of Length of Virtual Stents in Treatment of Intracranial Wide-Necked Aneurysms. [PDF]

, 2019
Background and purposePrecise stent deployment is important for successful treatment of intracranial aneurysms by stent-assisted coiling (SAC). We evaluated the accuracy of virtual stents generated using commercial stent planning software by comparing ...
Dahmani, Chihebeddine, Ishibashi, Toshihiro, Kaku, Shogo, Mohamed, Ashraf, Murayama, Yuichi, Nishimura, Kengo, Otani, Katharina, Takao, Hiroyuki, Yuki, Ichiro   +8 more
core  

Wearable Battery‐Free Electrotherapy of Smartsensors for Wound Healthcare

Advanced Science, EarlyView.
Herein, we propose a simple strategy for integrating battery‐free electrotherapy wound dressings with wound sensors. Solid‐state supercapacitors constructed by PMAB with cross‐linked interpenetrating network provide energy for electrotherapy. Meanwhile, excellent mechanical sensing performance of wound dressing was used for wound assessment.
Wenrui Zhang, Qian Lin, Jiancheng Zhang, Hao Mo, Wencheng Li, Yicheng Hu, Hongting Ma, Dan Zhao, Hongnv Yu, Nan Zhu   +9 more
wiley   +1 more source

Management of intracranial aneurysms: a 2024 nationwide study from China

Journal of Stroke and Cerebrovascular Diseases
Background: Rising detection of unruptured intracranial aneurysms (UIAs) in China, driven by an aging population and increased neuroimaging utilization, coincides with significant regional disparities in neurointerventional resources.
Yu Gao, MS, Meihua Huyan, MD, Yina Wu, MD, Zhao Dai, MS, Yongwei Zhang, MD, Jianmin Liu, MD, Pengfei Yang, MD, Rui Zhao, MD, Qiang Li, MD   +8 more
doaj   +1 more source

Applicability of fluidic controls to a Rankine cycle automotive engine Final report [PDF]

Fluidic controls for automotive engine examined by Rankine cycle performance with water, CP-34, and freon TF and investigation for boiler and feed pump control ...
Fisher, E. J., Murray, R. I., Weissenberger, S.   +2 more
core   +1 more source

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

The Use of Prasugrel and Ticagrelor in Pipeline Flow Diversion [PDF]

, 2018
Background: Despite the routine clopidogrel/aspirin anti-platelet therapy, complications like thromboembolism, continue to be encountered with PED.
Atallah, MD, Elias, Bekelis, MD, Kimon, Chalouhi, MD, Nohra, Eller, MD, Gorge, Hasan, MD, David, Jabbour, Pascal, MD, Rosenwasser, MD, MBA, FACS, FAHA MD, Robert H., Saad, MD, Hassan, Stidd, MD, David, Tjoumakaris, MD, Stavropoula   +9 more
core   +2 more sources