Results 51 to 60 of about 124,436 (288)

Partition-Induced Vector Chromatography in Microfluidic Devices

, 2010
The transport of Brownian particles in a slit geometry in the presence of an arbitrary two-dimensional periodic energy landscape and driven by an external force or convected by a flow field is investigated by means of macrotransport theory.
Bahukudumbi, Balvin, Bhagat, Brenner, Brenner, Burada, Carlo, Choi, Choi, Choi, Davis, Dorfman, Dorfman, Eijkel, Ermak, Evander, Frechette, Gascoyne, German Drazer, Giddings, Giddings, Giddings, Giddings, Han, Han, Happel, Herrmann, Huang, Hughes, Jacobs, Jonáš, Jorge A. Bernate, Kovarik, Kowalkowski, Kralj, Kulrattanarak, Laachi, Li, Mao, Morton, Morton, Pamme, Pamme, Park, Pawar, Risken, Sai, Staben, Takagi, Vastamäki, Wang, Wu, Yamada, Yamada, Zwanzig   +54 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Soil water stable isotopes reveal evaporation dynamics at the soil–plant–atmosphere interface of the critical zone [PDF]

, 2017
Acknowledgements. We are thankful for the support by Audrey Innes during all laboratory work. We further thank Jonathan Dick for running the isotope analysis of precipitation samples and Annette C. Raffan for her support in the soil texture analysis.
Soulsby, Chris, Sprenger, Matthias, Tetzlaff, Doerthe   +2 more
core   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A DNA aptamer for binding and inhibition of DNA methyltransferase 1. [PDF]

, 2019
DNA methyltransferases (DNMTs) are enzymes responsible for establishing and maintaining DNA methylation in cells. DNMT inhibition is actively pursued in cancer treatment, dominantly through the formation of irreversible covalent complexes between small ...
Adkins, Gary Brent, Duan, Yaokai, Fang, Jian, Gao, Linfeng, Jimenez, Luis A, Lee, Ju Yong, Li, Linhui, Ren, Wendan, Song, Jikui, Wang, Linlin, Wang, Yinsheng, Yin, Jiekai, Zhong, Wenwan   +12 more
core  

Modelling and experimental study of separators for co-solvent recovery in a supercritical extraction process [PDF]

, 2006
Co-solvent recovery in supercritical extraction is addressed here through a theoretical description of the behaviour of a CO2 + co-solvent mixture into a cascade of cyclonic separators, such as those existing in conventional fractionation processes based
Camy, Séverine, Condoret, Jean-Stéphane   +1 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effects of Angular Dependency of Particulate Light Scattering Intensity on Determination of Samples with Bimodal Size Distributions Using Dynamic Light Scattering Methods

Nanomaterials, 2018
The angular dependency of light scattering intensity from differently sized particles strongly influences the apparent particle size distribution, as determined by dynamic light scattering (DLS) methods. Manufactured nanomaterials have size distributions
Haruhisa Kato, Ayako Nakamura, Shinichi Kinugasa   +2 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source