Results 101 to 110 of about 1,337,593 (318)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A Class of Three-Dimensional Optimum Wings in Hypersonic Flow [PDF]

, 1967
The idea of using streamlines of a certain known flow field to construct generally three-dimensional lifting surfaces together with the method of evaluating the aerodynamic forces on the surfaces, developed by Nonweiler, Jones and Woods, has been ...
Zien, Tse-Fou
core   +1 more source

Analysis and Elimination of the Cause of Furnace Slagging in a Supercritical Slit Type Burner W-Flame Boiler

发电技术, 2018
In order to study the slagging reason of a 600 MW supercritical W-flame boiler, a test study is carried out. The content includes the slagging position detection, gas composition measurement, the temperature distribution measurement and numerical ...
Pengzhi XU, Pengyuan LIU, Jiajia GAO, Jianping HUANG, Guifu WU, Wen TANG   +5 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Blood flow in microvascular networks [PDF]

, 2009
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
Mansour, MH, 2nd Micro and Nano Flows Conference (MNF2009), Shearman, CP, Bressloff, NW   +3 more
core  

Numerical Study of Nanoparticle Coagulation in Non-Road Diesel Engine Exhaust Based on the Principle of Split-Stream Rushing

Energies
Diesel engines employed in non-road machinery are significant contributors to nanoparticulate matters. This paper presents a novel device based on the principle of split-stream rushing to mitigate particulate matter emissions from these engines.
Yuchen Guo, Pei Wu, He Su, Jing Xue, Yongan Zhang, Peiyan Huang   +5 more
doaj   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Two-phase numerical study of the flow field formed in water pump sump: influence of air entrainment [PDF]

, 2009
In a pump sump it is imperative that the amount of non-homogenous flow and entrained air be kept to a minimum. Free air-core vortex occurring at a water-intake pipe is an important problem encountered in hydraulic engineering.
Abustam, Effendi, Ginger, John, Jayashree, Sreenivasan, A Issa, Holmes, John, Edwards, Mark, Ho, Sin Ban, Wehner, Martin, John Ginger, Carl Sandland, ISSA, Abir, Tan, Chuie Hong, G Bois, Bayeul, Annie-Claude, Mark Edwards, John Holmes, Mohiuddin, M., Martin Wehner, BOIS, Gérard, S Simonet, Cocklin, Chris R., BAYEUL-LAINÉ, Annie-Claude, Said, Muhammad Irfan, SIMONET, Sophie, Sandland, Carl, Yusuf, Muhammad, A C Bayeul-Lainé, Dibden, Jacqui, Reza, M. N. H.   +28 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source