Results 101 to 110 of about 4,414,012 (305)

c-theorem of the entanglement entropy

, 2018
We holographically investigate the renormalization group flow in a two-dimensional conformal field theory deformed by a relevant operator. If the relevant operator allows another fixed point, the UV conformal field theory smoothly flows to a new IR ...
Lee, Jung Hun, Park, Chanyong, Ro, Daeho
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

The Interplay of Magnetic Fields, Fragmentation and Ionization Feedback in High-Mass Star Formation

, 2011
Massive stars disproportionately influence their surroundings. How they form has only started to become clear recently through radiation gas dynamical simulations.
Arce, Bally, Banerjee, Banerjee, Beuther, Blandford, Bürzle, Cai, Crutcher, Crutcher, Crutcher, Federrath, Fryxell, Goldreich, Hennebelle, Keto, Kim, Kim, Königl, Lada, Lovelace, Matsumoto, Matsumoto, McKee, Mordecai-Mark Mac Low, Mouschovias, Mueller, Peters, Peters, Peters, Ralf S. Klessen, Remijan, Robi Banerjee, Shu, Strittmatter, Thomas Peters, Tomida, Tomisaka, Tomisaka, Uchida, Vaidya, Wang   +41 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Effect of Parameters of Ditch Geometry on the Uniformity of Water Filling in Ship Lock Chambers

Journal of Marine Science and Engineering
The design of ditch structures in ship locks has an important influence on reducing water flow energy, improving the uniformity of water filling in lock chambers, and reducing the force acting on mooring ships.
Qiaoyi Hu, Yun Li, Long Zhu
doaj   +1 more source

Phase-field simulation of core-annular pipe flow

, 2019
Phase-field methods have long been used to model the flow of immiscible fluids. Their ability to naturally capture interface topological changes is widely recognized, but their accuracy in simulating flows of real fluids in practical geometries is not ...
Avila, Marc, Lopez, Jose M., Plana, Carlos, Song, Baofang   +3 more
core   +1 more source

Field-flow fractionation [PDF]

Analytical and Bioanalytical Chemistry, 2014
S Kim R, Williams, Karin D, Caldwell
openaire   +2 more sources